Visual cortical regions show sufficient test-retest reliability while salience regions are unreliable during emotional face processing.
Visual cortical regions show sufficient test-retest reliability while salience regions are unreliable during emotional face processing.
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DOI：
10.1016/j.neuroimage.2020.117077
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发表时间：
2020-10-15
期刊：
影响因子：
5.7
通讯作者：
Aupperle RL
中科院分区：
文献类型：
--
作者：
McDermott TJ;Kirlic N;Akeman E;Touthang J;Cosgrove KT;DeVille DC;Clausen AN;White EJ;Kuplicki R;Aupperle RL
功能性磁共振成像研究经常使用情绪面部处理任务来探测与精神疾病和治疗相关的神经回路，重点是突出网络内的区域（例如，杏仁核）。在以往的情绪面孔处理的重测信度研究的结果表明，高变异性，可能是由于数据分析方法的差异。本研究全面研究了重测信度的情绪面孔任务，利用多种方法的兴趣区（ROI）分析，并通过检查整个大脑的神经激活和功能连接的体素可靠性。分析包括42名健康的成年参与者，他们在两天内完成了fMRI扫描，同时完成了情绪面孔任务，扫描之间的平均间隔为25.52天。针对“FACES-SHAPES”和“FACES”（与隐式基线相比）对比计算组内相关系数（ICC），包括：从公开可用的脑图谱中识别的解剖ROI（即，Brainnetome），由来自公开可用的元分析数据库的峰值体素上的5 mm球体组成的功能ROI（即，Neurosynth）和全脑体素分析。还使用解剖学和功能种子ROI进行了全脑功能连接的体素分析。虽然组平均神经激活图在不同时间是一致的，但只有一个解剖ROI和两个功能ROI显示出神经激活的良好或优秀的个体水平可靠性。解剖学ROI是用于FACES对比的右侧中腹梭状回（ICC = 0.60）。功能性ROI为FACES-SHAPES和FACES的左和右梭状面区（FFA）（左FFA ICC = 0.69和0.79;右FFA ICC = 0.68和0.66）。几乎所有其他解剖和功能ROI的可靠性都较差（ICC < 0.4），但有一些例外显示出相当的可靠性（ICC = 0.4-0.59）。神经激活的全脑体素分析识别出具有良好（ICC = 0.6-0.74）至优异可靠性（ICC> 0.75）的体素，其主要位于视觉皮层中，在双侧背外侧前额叶皮层（DLPFC）中具有若干簇。杏仁核和梭状回的功能连接的全脑体素明智的分析确定了很少的体素具有良好的可靠性，使用解剖和功能种子ROI。右侧小脑和右侧DLPFC中的神经元簇显示与左侧杏仁核的可靠连接（ICC> 0.6）。总之，结果表明，视觉皮层区域在神经激活的个体水平上表现出良好的可靠性，但对于精神病学研究中经常关注的显著区域（例如，杏仁核）。鉴于这些发现，未来的临床神经影像学研究使用情绪面孔任务来检查个体差异，可能会转而关注视觉区域及其在精神疾病中的作用。
Functional magnetic resonance imaging studies frequently use emotional face processing tasks to probe neural circuitry related to psychiatric disorders and treatments with an emphasis on regions within the salience network (e.g., amygdala). Findings across previous test-retest reliability studies of emotional face processing have shown high variability, potentially due to differences in data analytic approaches. The present study comprehensively examined the test-retest reliability of an emotional faces task utilizing multiple approaches to region of interest (ROI) analysis and by examining voxel-wise reliability across the entire brain for both neural activation and functional connectivity. Analyses included 42 healthy adult participants who completed an fMRI scan concurrent with an emotional faces task on two separate days with an average of 25.52 days between scans. Intraclass correlation coefficients (ICCs) were calculated for the ‘FACES-SHAPES’ and ‘FACES’ (compared to implicit baseline) contrasts across the following: anatomical ROIs identified from a publicly available brain atlas (i.e., Brainnetome), functional ROIs consisting of 5-mm spheres centered on peak voxels from a publicly available meta-analytic database (i.e., Neurosynth), and whole-brain, voxel-wise analysis. Whole-brain, voxel-wise analyses of functional connectivity were also conducted using both anatomical and functional seed ROIs. While group-averaged neural activation maps were consistent across time, only one anatomical ROI and two functional ROIs showed good or excellent individual-level reliability for neural activation. The anatomical ROI was the right medioventral fusiform gyrus for the FACES contrast (ICC = 0.60). The functional ROIs were the left and the right fusiform face area (FFA) for both FACES-SHAPES and FACES (Left FFA ICCs = 0.69 & 0.79; Right FFA ICCs = 0.68 & 0.66). Poor reliability (ICCs < 0.4) was identified for almost all other anatomical and functional ROIs, with some exceptions showing fair reliability (ICCs = 0.4–0.59). Whole-brain voxel-wise analysis of neural activation identified voxels with good (ICCs = 0.6–0.74) to excellent reliability (ICCs > 0.75) that were primarily located in visual cortex, with several clusters in bilateral dorsal lateral prefrontal cortex (DLPFC). Whole-brain voxel-wise analyses of functional connectivity for amygdala and fusiform gyrus identified very few voxels with good to excellent reliability using both anatomical and functional seed ROIs. Exceptions included clusters in right cerebellum and right DLPFC that showed reliable connectivity with left amygdala (ICCs > 0.6). In conclusion, results indicate that visual cortical regions demonstrate good reliability at the individual level for neural activation, but reliability is generally poor for salience regions often focused on within psychiatric research (e.g., amygdala). Given these findings, future clinical neuroimaging studies using emotional faces tasks to examine individual differences might instead focus on visual regions and their role in psychiatric disorders.
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影响因子：
2.9
作者：
Bruehl, Annette B.;Rufer, Michael;Herwig, Uwe
通讯作者：
Herwig, Uwe
影响因子：
6.8
作者：
Godlewska BR;Browning M;Norbury R;Cowen PJ;Harmer CJ
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人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
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Jiang T
影响因子：
4.3
作者：
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作者：
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通讯作者：
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