Fully Automated Biometry of In Situ Intraocular Lenses Using Long Scan Depth Spectral-Domain Optical Coherence Tomography
Fully Automated Biometry of In Situ Intraocular Lenses Using Long Scan Depth Spectral-Domain Optical Coherence Tomography
复制标题
使用长扫描深度谱域光学相干断层扫描对原位人工晶状体进行全自动生物测量
DOI：
10.1097/icl.0000000000000005
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Shen, Meixiao
中科院分区：
文献类型：
--
作者：
Shao, Yilei;Wang, Jianhua;Lu, Fan;Shen, Meixiao
目的：采用光谱域光学相干断层扫描（SD-OCT）自动测量植入人工透镜（IOL）的眼前节的屈光性生物特征变化。自动化测量的可重复性和可靠性也进行了评价。方法：应用长扫描深度SD-OCT对人工晶状体植入眼进行眼前节成像。使用全自动算法检测角膜和IOL的边界并获得测量结果。结果包括IOL眼的前段尺寸和IOL的偏转。在体外对自动测量进行了验证，并将其与植入IOL患者的15张横截面图像的体内手动结果进行了比较。分别入组了5只装有5种不同类型IOL的眼睛，以测试调节期间自动测量的可重复性。结果如下：长扫描深度SD-OCT在体外和模型眼中测量的人工透镜中心厚度和前后曲率半径与千分尺卡尺和干涉仪测定的结果匹配良好。在体内，通过自动和手动分割确定的生物计量数据具有良好的相关性（P<0.05，r值范围：0.635-0.997）。两种测量方法在各呼吸状态下的各项指标均无显著性差异（P>0.05）。前房深度和瞳孔直径在非屈光状态和2.5-D屈光状态之间有显著性变化（P<0.05），而人工晶状体的形状无显著性变化（P>0.05）。结论：经验证，采用自动算法的长扫描深度SD-OCT在研究植入IOL和IOL偏转的眼前段的生物计量学变化方面具有很大的潜力。
Purpose: Spectral-domain optical coherence tomography (SD-OCT) was used to automatically measure accommodative biometric changes in the anterior segment of eyes implanted with an intraocular lens (IOL). The repeatability and reliability of the automated measurements were also evaluated. Methods: Long scan depth SD-OCT was used to image the anterior segment of eyes implanted with IOLs. A fully automated algorithm was used to detect the boundaries of the cornea and IOL and yielded the measurements. The results included anterior segment dimensions in IOL eyes and the deflection of the IOLs. Automated measurements were validated in vitro and compared with the manual results in vivo on 15 cross-sectional images from patients with IOLs. Five eyes with five different types of IOLs, respectively, were enrolled to test the repeatability of the automated measurements during accommodation. Results: Intraocular lens central thickness and anterior and posterior curvature radii measured by long scan depth SD-OCT in vitro and in a model eye matched well with those determined by a micrometer caliper and interferometer. In vivo, there was good correlation of the biometric data determined by automated and manual segmentations (P<0.05, r-value range: 0.635–0.997). There were no significant differences for any variable between the two measurements at each accommodative state (P>0.05). Anterior chamber depth and pupil diameter showed significant changes between the nonaccommodative and 2.5-D accommodative states (P<0.05), whereas the shape of the IOLs did not change significantly (P>0.05). Conclusions: The long scan depth SD-OCT with the automated algorithm was verified to have a great potential in studying accommodative biometric changes of the anterior segment in eyes with IOLs and IOL deflections.
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影响因子：
13.7
作者：
Kriechbaum, K;Findl, O;Drexler, W
通讯作者：
Drexler, W
影响因子：
4.4
作者：
T. Oshika;T. Mimura;Sumiyoshi Tanaka;S. Amano;M. Fukuyama;F. Yoshitomi;N. Maeda;T. Fujikado;Y. Hirohara;T. Mihashi
通讯作者：
T. Oshika;T. Mimura;Sumiyoshi Tanaka;S. Amano;M. Fukuyama;F. Yoshitomi;N. Maeda;T. Fujikado;Y. Hirohara;T. Mihashi
影响因子：
2.8
作者：
de Castro, Alberto;Rosales, Patricia;Marcos, Susana
通讯作者：
Marcos, Susana
影响因子：
13.7
作者：
McKelvie, James;McArdle, Brian;McGhee, Charles
通讯作者：
McGhee, Charles
影响因子：
3.8
作者：
Yang Q;Reisman CA;Wang Z;Fukuma Y;Hangai M;Yoshimura N;Tomidokoro A;Araie M;Raza AS;Hood DC;Chan K
通讯作者：
Chan K