Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation.
Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation.
复制标题
对表达阵列数据进行生物信息学询问，以识别可能受 DNA 甲基化调节的营养调节基因。
DOI：
10.1007/s12263-008-0095-0
复制
发表时间：
2008-12
影响因子：
3.5
通讯作者：
Mathers, J. C.
中科院分区：
文献类型：
--
作者：
McKay, J. A.;Adriaens, M. E.;Ford, D.;Relton, C. L.;Evelo, C. T. A.;Mathers, J. C.
关键词：
DNA methylation occurs at CpG dinucleotide sites within the genome and is recognised as one of the mechanisms involved in regulation of gene expression. CpG sites are relatively underrepresented in the mammalian genome, but occur densely in regions called CpG islands (CGIs). CGIs located in the promoters of genes inhibit transcription when methylated by impeding transcription factor binding. Due to the malleable nature of DNA methylation, environmental factors are able to influence promoter CGI methylation patterns and thus influence gene expression. Recent studies have provided evidence that nutrition (and other environmental exposures) can cause altered CGI methylation but, with a few exceptions, the genes influenced by these exposures remain largely unknown. Here we describe a novel bioinformatics approach for the analysis of gene expression microarray data designed to identify regulatory sites within promoters of differentially expressed genes that may be influenced by changes in DNA methylation.
登录
查看更多内容
影响因子：
3
作者：
van Iersel MP;Kelder T;Pico AR;Hanspers K;Coort S;Conklin BR;Evelo C
通讯作者：
Evelo C
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.6
作者：
Lillycrop, Karen A.;Phillips, Emma S.;Torrens, Christopher;Hanson, Mark A.;Jackson, Alan A.;Burdge, Graham C.
通讯作者：
Burdge, Graham C.
影响因子：
4.2
作者：
Lillycrop, KA;Phillips, ES;Burdge, GC
通讯作者：
Burdge, GC
影响因子：
5.8
作者：
Cartharius, K;Frech, K;Werner, T
通讯作者：
Werner, T