PHF10 subunit of PBAF complex mediates transcriptional activation by MYC.
PHF10 subunit of PBAF complex mediates transcriptional activation by MYC.
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DOI：
10.1038/s41388-021-01994-0
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发表时间：
2021-10
期刊：
影响因子：
8
通讯作者：
Georgieva SG
中科院分区：
文献类型：
--
作者：
Soshnikova NV;Tatarskiy EV;Tatarskiy VV;Klimenko NS;Shtil AA;Nikiforov MA;Georgieva SG
The PBAF complex, a member of SWI/SNF family of chromatin remodelers, plays an essential role in transcriptional regulation. We revealed a disease progression associated elevation of PHF10 subunit of PBAF in clinical melanoma samples. In melanoma cell lines, PHF10 interacts with MYC and facilitates the recruitment of PBAF complex to target gene promoters, therefore augmenting MYC transcriptional activation of genes involved in the cell cycle progression. Depletion of either PHF10 or MYC induced G1 accumulation and a senescence-like phenotype. Our data identify PHF10 as a pro-oncogenic mechanism and an essential novel link between chromatin remodeling and MYC-dependent gene transcription.
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