Association of parity with birthweight and neonatal death in five sites: The Global Network's Maternal Newborn Health Registry study.
Association of parity with birthweight and neonatal death in five sites: The Global Network's Maternal Newborn Health Registry study.
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五个地点的均等与出生体重和新生儿死亡的关联：全球网络的新生儿卫生注册表研究。
DOI：
10.1186/s12978-020-01025-3
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发表时间：
2020-12-17
影响因子：
3.4
通讯作者：
Hambidge KM
中科院分区：
文献类型：
--
作者：
Garces A;Perez W;Harrison MS;Hwang KS;Nolen TL;Goldenberg RL;Patel AB;Hibberd PL;Lokangaka A;Tshefu A;Saleem S;Goudar SS;Derman RJ;Patterson J;Koso-Thomas M;McClure EM;Krebs NF;Hambidge KM
无产与出生体重较低和其他不良妊娠结局有关，大部分数据来自高收入国家。在这项研究中，我们检查了出生体重胎龄z评分和新生儿（28天）死亡率在一个大型的前瞻性队列的妇女在孕早期超声日期从多个网站在低收入和中等收入国家。2017年至2018年，在刚果民主共和国（DRC）、危地马拉、贝拉加维和印度那格布尔（纳格布尔）以及巴基斯坦的孕产妇新生儿健康登记处（MNHR）地点招募了怀孕前三个月的孕妇，并对产后6周进行了随访。前瞻性收集妊娠及其结局相关数据。孕早期超声用于确定胎龄;（BW）在分娩后48小时内以克为单位获得，随后使用INTERGROWTH-21标准转换为针对胎龄调整的年龄别体重z评分（WAZ）。15，121名女性符合条件并被纳入其中。与有一次或多次妊娠的女性相比，未经产女性的婴儿的平均BW（男性：2676 gr，女性：2587 gr，总体重：2634 gr）和胎龄校正体重年龄z评分（男性：-0.73，女性：-0.77，总体重：-0.75）较低。在女婴中，最大的差异是以前怀孕零次和一次。即使在调整了母亲年龄、母亲身高、母亲受教育程度、产前检查、高血压疾病和社会经济地位后，胎次与BW和Z评分的相关性仍然存在。未生育妇女的< 28天新生儿死亡率（每1 000例活产27.7例）也显著高于经产妇女（1-3胎次和≥ 4胎次分别为17.2和20.7例）。既往妊娠≥ 4次的女性早产风险较高（15.5%），而未经产组为11.3%，既往妊娠1 - 3次的女性为11.8%（p = 0.0072）。在这个来自不同环境的大样本中，与多产相比，未经产与较低的BW和WAZ评分以及较高的新生儿死亡率独立相关。
Nulliparity has been associated with lower birth weight (BW) and other adverse pregnancy outcomes, with most of the data coming from high-income countries. In this study, we examined birth weight for gestational age z-scores and neonatal (28-day) mortality in a large prospective cohort of women dated by first trimester ultrasound from multiple sites in low and middle-income countries. Pregnant women were recruited during the first trimester of pregnancy and followed through 6 weeks postpartum from Maternal Newborn Health Registry (MNHR) sites in the Democratic Republic of Congo (DRC), Guatemala, Belagavi and Nagpur, India, and Pakistan from 2017 and 2018. Data related to the pregnancy and its outcomes were collected prospectively. First trimester ultrasound was used for determination of gestational age; (BW) was obtained in grams within 48 h of delivery and later transformed to weight for age z-scores (WAZ) adjusted for gestational age using the INTERGROWTH-21st standards. 15,121 women were eligible and included. Infants of nulliparous women had lower mean BWs (males: 2676 gr, females: 2587 gr, total: 2634 gr) and gestational age adjusted weight for age z-scores (males: − 0.73, females: − 0.77, total: − 0.75,) than women with one or more previous pregnancies. The largest differences were between zero and one previous pregnancies among female infants. The associations of parity with BW and z-scores remained even after adjustment for maternal age, maternal height, maternal education, antenatal care visits, hypertensive disorders, and socioeconomic status. Nulliparous women also had a significantly higher < 28-day neonatal mortality rate (27.7 per 1,000 live births) than parous women (17.2 and 20.7 for parity of 1–3 and ≥ 4 respectively). Risk of preterm birth was higher among women with ≥ 4 previous pregnancies (15.5%) compared to 11.3% for the nulliparous group and 11.8% for women with one to three previous pregnancies (p = 0.0072). In this large sample from diverse settings, nulliparity was independently associated with both lower BW and WAZ scores as well as higher neonatal mortality compared to multiparity.
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影响因子：
3.8
作者：
Goudar, Shivaprasad S.;Carlo, Waldemar A.;McClure, Elizabeth M.;Pasha, Omrana;Patel, Archana;Esamai, Fabian;Chomba, Elwyn;Garces, Ana;Althabe, Fernando;Kodkany, Bhalachandra;Sami, Neelofar;Derman, Richard J.;Hibberd, Patricia L.;Liechty, Edward A.;Krebs, Nancy F.;Hambidge, K. Michael;Buekens, Pierre;Moore, Janet;Wallace, Dennis;Jobe, Alan H.;Koso-Thomas, Marion;Wright, Linda L.;Goldenberg, Robert L.
通讯作者：
Goldenberg, Robert L.
影响因子：
3.1
作者：
Hoffman, Matthew K.;Goudar, Shivaprasad S.;Derman, Richard J.
通讯作者：
Derman, Richard J.
影响因子：
2.8
作者：
Hinkle SN;Albert PS;Mendola P;Sjaarda LA;Yeung E;Boghossian NS;Laughon SK
通讯作者：
Laughon SK
影响因子：
3.1
作者：
Pasha O;Goldenberg RL;McClure EM;Saleem S;Goudar SS;Althabe F;Patel A;Esamai F;Garces A;Chomba E;Mazariegos M;Kodkany B;Belizan JM;Derman RJ;Hibberd PL;Carlo WA;Liechty EA;Hambidge KM;Buekens P;Wallace D;Howard-Grabman L;Stalls S;Koso-Thomas M;Jobe AH;Wright LL
通讯作者：
Wright LL
影响因子：
7.7
作者：
Chen, Xi-Kuan;Wen, Shi Wu;Walker, Mark
通讯作者：
Walker, Mark