The association between parity and birthweight in a longitudinal consecutive pregnancy cohort.
The association between parity and birthweight in a longitudinal consecutive pregnancy cohort.
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DOI：
10.1111/ppe.12099
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发表时间：
2014-03
影响因子：
2.8
通讯作者：
Laughon SK
中科院分区：
文献类型：
--
作者：
Hinkle SN;Albert PS;Mendola P;Sjaarda LA;Yeung E;Boghossian NS;Laughon SK
无产与低出生体重有关，但很少有研究调查母亲内部风险因素的变化如何影响这种联系。我们使用的纵向电子医疗记录数据来自犹他州2002-2010年连续单胎活产的医院队列。为了减少未观察到的妊娠的偏倚，主要分析限于2002-2004年间9484名未分娩的妇女，其中23380名怀孕至胎次3。不受限制的二次分析使用了来自45212名怀孕至胎次的妇女的101225例妊娠。我们计算胎龄和性别特异性出生体重z-score，以nulliparas为参考。使用线性混合模型，我们通过胎次调整怀孕特定社会人口统计学、吸烟、酒精、孕前体重指数、妊娠期体重增加和医疗条件来估计出生体重z分数。与未分娩的婴儿相比，初产婴儿的未调整z-score单位大0.20[95%置信区间（CI） 0.18, 0.22]；调整后的增幅相似，为0.18 z-score单位[95% CI 0.15, 0.20]。出生体重继续增加到第三胎次，但差异较小（第三胎次vs. 0 β=0.27 [95% CI 0.20, 0.34]）。在不受限制的二次样本中，从宇称1到宇称7存在显著的线性偏离（P<0.001）；出生体重仅增加到胎次4（胎次4 vs. 0 β=0.34 [95% CI 0.31, 0.37]）。胎次和出生体重之间的关系是非线性的，在同一母亲的第一胎和第二胎婴儿之间观察到最大的增加。调整体重或慢性疾病的变化并没有改变胎次和出生体重之间的关系。
Nulliparity is associated with lower birthweight, but few studies have examined how within mother changes in risk-factors impact this association. We used longitudinal electronic medical record data from a hospital-based cohort of consecutive singleton live births from 2002–2010 in Utah. To reduce bias from unobserved pregnancies primary analyses were limited to 9,484 women who entered nulliparous from 2002–2004 with 23,380 pregnancies up to parity 3. Unrestricted secondary analyses used 101,225 pregnancies from 45,212 women with pregnancies up to parity 7. We calculated gestational age and sex-specific birthweight z-scores with nulliparas as the reference. Using linear mixed models, we estimated birthweight z-score by parity adjusting for pregnancy-specific sociodemographics, smoking, alcohol, prepregnancy body mass index, gestational weight gain, and medical conditions. Compared to nulliparas, infants of primiparas were larger by 0.20 unadjusted z-score units [95% confidence interval (CI) 0.18, 0.22]; the adjusted increase was similar at 0.18 z-score units [95% CI 0.15, 0.20]. Birthweight continued to increase up to parity 3, but with a smaller difference, (parity 3 vs. 0 β=0.27 [95% CI 0.20, 0.34]). In the unrestricted secondary sample, there was significant departure in linearity from parity 1 to 7 (P<0.001); birthweight increased only up to parity 4, (parity 4 vs. 0 β=0.34 [95% CI 0.31, 0.37]). The association between parity and birthweight was non-linear with the greatest increase observed between first and second-born infants of the same mother. Adjustment for changes in weight or chronic diseases did not change the relationship between parity and birthweight.
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影响因子：
3.3
作者：
Miranda, Marie Lynn;Edwards, Sharon E.;Myers, Evan R.
通讯作者：
Myers, Evan R.
DOI：
10.1111/j.1471-0528.2012.03313.x
发表时间：
2012-06-01
影响因子：
5.8
作者：
Anderson, N. H.;Sadler, L. C.;McCowan, L. M. E.
通讯作者：
McCowan, L. M. E.
影响因子：
2.6
作者：
Andrade, Susan E.;Simas, Tiffany A. Moore;Platt, Richard
通讯作者：
Platt, Richard
影响因子：
2.8
作者：
Luo, Zhong-Cheng;An, Na;Fraser, William D.
通讯作者：
Fraser, William D.
影响因子：
2.8
作者：
Krulewitch, CJ;Herman, AA;Johnson, YR
通讯作者：
Johnson, YR