The effects of dexamethasone on transcapillary transport in experimental brain tumors: II. Canine brain tumors.
The effects of dexamethasone on transcapillary transport in experimental brain tumors: II. Canine brain tumors.
复制标题
地塞米松对实验性脑肿瘤经毛细血管转运的影响：II。
DOI：
10.1007/bf01054720
复制
发表时间：
1995
影响因子：
3.9
通讯作者：
Groothuis,DR
中科院分区：
文献类型：
--
作者：
Warnke,PC;Molnar,P;Lapin,GD;Kuruvilla,A;Groothuis,DR
We studied the effect of dexamethasone on transcapillary transport in ten Avian Sarcoma Virus (ASV)-induced canine brain tumors, before and one week after administration of dexamethasone, 2.5 mg/kg/day. A computed tomographic (CT) method was used to measure regional values of K1(blood-to-tissue transfer constant), k2(tissue-to-blood efflux constant), and Vp(tissue plasma vascular space) of meglumine iothalamate (Conray-60TM); the values were reconstructed for each 0.8 × 0.8 x 5 mm volume element of the CT data. For all tumors considered together, there was a decrease in the whole tumor K1value of meglumine iothalamate from 26 ± 2.2 (SE) before dexamethasone to 24 ± 2.9 μl/g/min after dexamethasone. Vpdecreased from 7.2 ± 0.7 to 6.7 ± 0.9 ml/100 g, and the size of the tumor extracellular space (Ve) decreased from 0.30 to 0.26 ml/g. These changes were not statistically significant. However, when each tumor was used as its own control, k1significantly decreased after dexamethasone in four tumors, significantly increased in two and was unchanged in four. These results suggest that decreased blood-to-tissue transport may be one mechanism underlying resolution of tumor associated cerebral edema in some brain tumors and that the effects of dexamethasone on blood-to-tissue transport in brain tumors are variable from one tumor to the next. Decreased ‘permeability’ may not be the sole mechanism by which dexamethasone reduces tumor-associated cerebral edema.
登录
查看更多内容
影响因子：
11.2
作者：
G. Erexson;J. Wilmer;A. Kligerman
通讯作者：
G. Erexson;J. Wilmer;A. Kligerman
苯酚在骨髓细胞中刺激对苯二酚的体外生物活化。
DOI：
--
发表时间：
1989
期刊：
Drug metabolism and disposition: the biological fate of chemicals
影响因子：
--
作者：
Subrahmanyam,V;Sadler,A;Suba,E;Ross,D
通讯作者：
Ross,D
DOI：
10.1016/0005-2760(72)90119-1
发表时间：
1972-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CHRIST, EJ;VANDORP, DA
通讯作者：
VANDORP, DA
反式，反式粘康酸，小鼠体内苯的开链尿代谢物。
DOI：
10.3109/00498258509045351
发表时间：
1985
期刊：
Xenobiotica; the fate of foreign compounds in biological systems
影响因子：
--
作者：
M. M. Gad;V. Ramanujam;M. Legator
通讯作者：
M. Legator
过氧化物酶催化 [U-14C] 苯酚与 DNA 的结合。
DOI：
10.3109/00498258509045037
发表时间：
1985
期刊：
Xenobiotica; the fate of foreign compounds in biological systems
影响因子：
--
作者：
V. Subrahmanyam;P. O'Brien
通讯作者：
P. O'Brien