Unambiguous identification of superparamagnetic iron oxide particles through quantitative susceptibility mapping of the nonlinear response to magnetic fields.
Unambiguous identification of superparamagnetic iron oxide particles through quantitative susceptibility mapping of the nonlinear response to magnetic fields.
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DOI:
10.1016/j.mri.2010.06.011
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发表时间:
2010-11
影响因子:
2.5
通讯作者:
Wang, Yi
中科院分区:
文献类型:
--
作者:
Liu, Tian;Spincemaille, Pascal;de Rochefort, Ludovic;Wong, Richard;Prince, Martin;Wang, Yi
Superparamagnetic iron oxide (SPIO) particles generate signal void regions on gradient echo images due to their strong magnetization. In practice, the signal void region might be indistinguishable from that generated by air. However, the response of SPIO to an externally applied magnetic field is non-linear. Magnetization of SPIO saturates at around 1 Tesla while magnetization of water and air increase linearly with field strength. Phantom experiment and mice experiments demonstrated the feasibility of a non-ambiguous identification of superparamagnetic contrast agents.
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