Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila.
Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila.
复制标题
DOI：
10.1016/j.celrep.2014.05.024
复制
发表时间：
2014-06-26
期刊：
影响因子：
8.8
通讯作者：
Jasper H
中科院分区：
文献类型：
--
作者：
Biteau B;Jasper H
为了维持组织稳态，干细胞谱系内的细胞命运决定必须响应组织的需求。这种谱系选择与再生需求的协调仍然缺乏特征。在这里，我们鉴定了来自肠内分泌细胞（EE）的信号，该信号控制果蝇肠道中的谱系规范。我们发现 EE 分泌 Slit，这是干细胞 (ISC) 中 Robo2 受体的配体，限制了 ISC 对内分泌谱系的承诺，从而建立了 EE 再生的负反馈控制。我们进一步表明，这种谱系决定是在 ISC 内做出的，并且需要在 ISC 中诱导转录因子 Prospero。我们的工作确定了保守的 Slit/Robo 通路在成体干细胞调节中的新功能，建立 ISC 谱系规范的负反馈控制作为保持组织稳态的关键策略。我们的结果进一步修正了目前对果蝇 ISC 谱系内细胞命运决定的理解。
To maintain tissue homeostasis, cell fate decisions within stem cell lineages have to respond to the needs of the tissue. This coordination of lineage choices with regenerative demand remains poorly characterized. Here we identify a signal from enteroendocrine cells (EEs) that controls lineage specification in the Drosophila intestine. We find that EEs secrete Slit, a ligand for the Robo2 receptor in stem cells (ISCs) that limits ISC commitment to the endocrine lineage, establishing negative feedback control of EE regeneration. We further show that this lineage decision is made within ISCs and requires induction of the transcription factor Prospero in ISCs. Our work identifies a new function for the conserved Slit/Robo pathway in the regulation of adult stem cells, establishing negative feedback control of ISC lineage specification as a critical strategy to preserve tissue homeostasis. Our results further amend the current understanding of cell fate commitment within the Drosophila ISC lineage.
登录
查看更多内容
影响因子：
4.5
作者：
Biteau B;Karpac J;Supoyo S;Degennaro M;Lehmann R;Jasper H
通讯作者：
Jasper H
DOI：
10.1634/stemcells.2008-0292
发表时间：
2009-01
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Shibata F;Goto-Koshino Y;Morikawa Y;Komori T;Ito M;Fukuchi Y;Houchins JP;Tsang M;Li DY;Kitamura T;Nakajima H
通讯作者：
Nakajima H
影响因子：
64.8
作者：
Biankin, Andrew V.;Waddell, Nicola;Kassahn, Karin S.;Gingras, Marie-Claude;Muthuswamy, Lakshmi B.;Johns, Amber L.;Miller, David K.;Wilson, Peter J.;Patch, Ann-Marie;Wu, Jianmin;Chang, David K.;Cowley, Mark J.;Gardiner, Brooke B.;Song, Sarah;Harliwong, Ivon;Idrisoglu, Senel;Nourse, Craig;Nourbakhsh, Ehsan;Manning, Suzanne;Wani, Shivangi;Gongora, Milena;Pajic, Marina;Scarlett, Christopher J.;Gill, Anthony J.;Pinho, Andreia V.;Rooman, Ilse;Anderson, Matthew;Holmes, Oliver;Leonard, Conrad;Taylor, Darrin;Wood, Scott;Xu, Qinying;Nones, Katia;Fink, J. Lynn;Christ, Angelika;Bruxner, Tim;Cloonan, Nicole;Kolle, Gabriel;Newell, Felicity;Pinese, Mark;Mead, R. Scott;Humphris, Jeremy L.;Kaplan, Warren;Jones, Marc D.;Colvin, Emily K.;Nagrial, Adnan M.;Humphrey, Emily S.;Chou, Angela;Chin, Venessa T.;Chantrill, Lorraine A.;Mawson, Amanda;Samra, Jaswinder S.;Kench, James G.;Lovell, Jessica A.;Daly, Roger J.;Merrett, Neil D.;Toon, Christopher;Epari, Krishna;Nguyen, Nam Q.;Barbour, Andrew;Zeps, Nikolajs;Kakkar, Nipun;Zhao, Fengmei;Wu, Yuan Qing;Wang, Min;Muzny, Donna M.;Fisher, William E.;Brunicardi, F. Charles;Hodges, Sally E.;Reid, Jeffrey G.;Drummond, Jennifer;Chang, Kyle;Han, Yi;Lewis, Lora R.;Dinh, Huyen;Buhay, Christian J.;Beck, Timothy;Timms, Lee;Sam, Michelle;Begley, Kimberly;Brown, Andrew;Pai, Deepa;Panchal, Ami;Buchner, Nicholas;De Borja, Richard;Denroche, Robert E.;Yung, Christina K.;Serra, Stefano;Onetto, Nicole;Mukhopadhyay, Debabrata;Tsao, Ming-Sound;Shaw, Patricia A.;Petersen, Gloria M.;Gallinger, Steven;Hruban, Ralph H.;Maitra, Anirban;Iacobuzio-Donahue, Christine A.;Schulick, Richard D.;Wolfgang, Christopher L.;Morgan, Richard A.;Lawlor, Rita T.;Capelli, Paola;Corbo, Vincenzo;Scardoni, Maria;Tortora, Giampaolo;Tempero, Margaret A.;Mann, Karen M.;Jenkins, Nancy A.;Perez-Mancera, Pedro A.;Adams, David J.;Largaespada, David A.;Wessels, Lodewyk F. A.;Rust, Alistair G.;Stein, Lincoln D.;Tuveson, David A.;Copeland, Neal G.;Musgrove, Elizabeth A.;Scarpa, Aldo;Eshleman, James R.;Hudson, Thomas J.;Sutherland, Robert L.;Wheeler, David A.;Pearson, John V.;McPherson, John D.;Gibbs, Richard A.;Grimmond, Sean M.
通讯作者：
Grimmond, Sean M.
影响因子：
4.6
作者：
Perdigoto, Carolina N.;Schweisguth, Francois;Bardin, Allison J.
通讯作者：
Bardin, Allison J.
影响因子：
16.2
作者：
Lee, T;Luo, LQ
通讯作者：
Luo, LQ