Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta.
Comprehensive characterization of elevated tau PET signal in the absence of amyloid-beta.
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DOI：
10.1093/braincomms/fcac272
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发表时间：
2022
影响因子：
4.8
通讯作者：
Bondi, Mark W.
中科院分区：
文献类型：
--
作者：
Weigand, Alexandra J.;Edwards, Lauren E.;Thomas, Kelsey R.;Bangen, Katherine J.;Bondi, Mark W.
最近提出的仅生物标志物的诊断框架提出，淀粉样蛋白-β对于放置在阿尔茨海默病连续体上是必需的，而在淀粉样蛋白-β不存在的情况下的tau被认为是非阿尔茨海默病的病理变化。类似地，在不存在淀粉样蛋白-β的情况下tau的病理学命名被表征为原发性年龄相关性tau病变，并且可与阿尔茨海默病分离。我们的研究试图使用PET成像识别具有最小淀粉样蛋白β的早期至中度tau阶段，并在临床，认知和生物学特征方面表征这些个体。来自阿尔茨海默病神经影像学倡议的703名参与者根据皮质淀粉样蛋白-β（A-/A+）和早期至中度（即后颞）tau（T-/T+）的PET阳性或阴性被分为四组（A-/T-，A-/T+，A+/T-和A+/T+）之一。然后比较这些组的人口统计学和临床特征、血管风险、多领域神经心理学表现、多领域主观认知主诉、载脂蛋白E β-4携带状态和阿尔茨海默病易感区域的皮质厚度。被划分到各组的参与者比例如下：A−/T− 47.23%，A−/T+13.51%，A+/T− 12.23%和A+/T+27.03%。结果表明，A−/T+和A+/T+组在年龄、性别、抑郁水平、血管风险和颞顶叶皮质厚度方面没有统计学差异。此外，A−/T+和A+/T+组的记忆表现与颞叶皮层厚度之间存在显著相关性。尽管A−/T+和A+/T+使用了不同的病理学术语，但这些组在许多临床、认知和生物标志物特征上没有统计学差异。虽然目前还不清楚A−/T+是否反映了与阿尔茨海默病可分离的病理结构，但我们的研究结果提供了证据，表明这组通常被表征为“非阿尔茨海默病病理变化”或“原发性年龄相关性tau蛋白病”的人群应该得到更多的关注，因为认知和生物标志物特征与传统上被认为是阿尔茨海默病连续体的人群有一些相似之处。Weigand等人报告称，一组在不存在淀粉样蛋白β的情况下具有tau PET证据的老年人表现出与传统上被认为处于阿尔茨海默病连续体的群体一致的临床、认知和生物标志物特征。
Recently proposed biomarker-only diagnostic frameworks propose that amyloid-beta is necessary for placement on the Alzheimer’s disease continuum, whereas tau in the absence of amyloid-beta is considered to be a non-Alzheimer’s disease pathologic change. Similarly, the pathologic designation of tau in the absence of amyloid-beta is characterized as primary age-related tauopathy and separable from Alzheimer’s disease. Our study sought to identify an early-to-moderate tau stage with minimal amyloid-beta using PET imaging and characterize these individuals in terms of clinical, cognitive and biological features. Seven hundred and three participants from the Alzheimer’s Disease Neuroimaging Initiative were classified into one of the four groups (A−/T−, A−/T+, A+/T− and A+/T+) based on PET positivity or negativity for cortical amyloid-beta (A−/A+) and early-to-moderate stage (i.e. meta-temporal) tau (T−/T+). These groups were then compared on demographic and clinical features, vascular risk, multi-domain neuropsychological performance, multi-domain subjective cognitive complaints, apolipoprotein E epsilon-4 carrier status and cortical thickness across Alzheimer’s disease-vulnerable regions. The proportion of participants classified in each group was as follows: 47.23% A−/T−, 13.51% A−/T+, 12.23% A+/T− and 27.03% A+/T+. Results indicated that the A−/T+ and A+/T+ groups did not statistically differ on age, sex, depression levels, vascular risk and cortical thickness across temporal and parietal regions. Additionally, both A−/T+ and A+/T+ groups showed significant associations between memory performance and cortical thickness of temporal regions. Despite the different pathologic terminology used for A−/T+ and A+/T+, these groups did not statistically differ on a number of clinical, cognitive and biomarker features. Although it remains unclear whether A−/T+ reflects a pathologic construct separable from Alzheimer’s disease, our results provide evidence that this group typically characterized as ‘non-Alzheimer’s pathologic change’ or ‘primary age-related tauopathy’ should be given increased attention, given some similarities in cognitive and biomarker characteristics to groups traditionally considered to be on the Alzheimer’s continuum. Weigand et al. report that a group of older adults with PET evidence of tau in the absence of amyloid-beta demonstrate clinical, cognitive and biomarker characteristics that are consistent with groups traditionally considered to be on the Alzheimer’s disease continuum.
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DOI：
10.1136/jnnp-2017-316402
发表时间：
2018-10
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Bevan-Jones WR;Cope TE;Jones PS;Passamonti L;Hong YT;Fryer TD;Arnold R;Allinson KSJ;Coles JP;Aigbirhio FI;Patterson K;O'Brien JT;Rowe JB
通讯作者：
Rowe JB
DOI：
10.1016/j.jalz.2015.05.005
发表时间：
2015-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Aisen PS;Petersen RC;Donohue M;Weiner MW;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
在厘米中的淀粉样蛋白宠物阳性阈值的验证：一种多站点PET研究方法。
DOI：
10.1186/s13195-021-00836-1
发表时间：
2021-05-10
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Royse SK;Minhas DS;Lopresti BJ;Murphy A;Ward T;Koeppe RA;Bullich S;DeSanti S;Jagust WJ;Landau SM;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
11.2
作者：
Boyle PA;Yu L;Wilson RS;Leurgans SE;Schneider JA;Bennett DA
通讯作者：
Bennett DA