Erythromycin-induced suppression of pulmonary antibacterial defenses. A potential mechanism of superinfection in the lung.
Erythromycin-induced suppression of pulmonary antibacterial defenses. A potential mechanism of superinfection in the lung.
复制标题
红霉素诱导的肺部抗菌防御抑制。
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
G. Jakab
中科院分区：
文献类型：
--
作者：
S. Nelson;Warren R. Summer;P. Terry;G. Warr;G. Jakab
红霉素是一种广谱抗生素，常用于呼吸道感染患者。其中某些患者会被新微生物定植并发生重复感染。抗生素除了简单地杀死或抑制细菌生长之外，还具有许多作用，并且可能对宿主细胞（包括吞噬细胞）产生直接影响。体外和体内研究表明，红霉素可减少多形核白细胞 (PMN) 定向迁移。为了测试红霉素抑制正常 PMN 迁移到肺泡以应对细菌攻击的假设，通过吸入奇异变形杆菌或金黄色葡萄球菌的气雾剂来攻击小鼠，并静脉注射红霉素（50 或 100 mg/kg）。细菌攻击后4小时测定肺部杀菌活性和总灌洗肺细胞和分类计数。在对照小鼠中，最初接种的奇异果在 4 小时内只有 24 +/- 2% 是存活的。在剂量为 100 mg/kg 时，红霉素后的肺部防御能力被消除，使得奇异变形杆菌增殖至初始接种量的 113 +/- 5%。奇异变形杆菌攻击后灌洗获得的中性粒细胞数量也受到红霉素的抑制，呈剂量依赖性。在未经治疗的动物中，随着红霉素剂量的增加，PMN 恢复了 5.0 +/- 0.2 x 10(6)，而与此相比，PMN 恢复了 3.1 +/- 0.4 x 10(6) 和 1.1 +/- 0.3 x 10(6)。红霉素不损害针对金黄色葡萄球菌的肺内杀菌活性。（摘要截断为 250 字）
Erythromycin is a broad-spectrum antibiotic commonly used in patients with respiratory infections. Certain of these patients become colonized with new microorganisms and develop superinfections. Antibiotics have a number of effects other than simply killing or inhibiting the growth of bacteria and may have direct effects upon host cells, including phagocytes. In vitro and in vivo studies have demonstrated that erythromycin decreases polymorphonuclear leukocyte (PMN) directed migration. To test the hypothesis that erythromycin inhibits normal PMN migration into the alveoli in response to a bacterial challenge, mice were challenged by aerosol inhalation with Proteus mirabilis or Staphylococcus aureus and injected intravenously with erythromycin (50 or 100 mg/kg). Pulmonary bactericidal activity and total lavaged lung cell and differential counts were determined 4 h after bacterial challenge. In control mice, only 24 +/- 2% of the initial inoculum of P. mirabilis was viable at 4 h. At a dose of 100 mg/kg, lung defenses after erythromycin were ablated, allowing the proliferation of P. mirabilis to 113 +/- 5% of the initial inoculum. The number of PMN obtained by lavage after P. mirabilis challenge was also inhibited by erythromycin in a dose-dependent manner. In untreated animals, 5.0 +/- 0.2 x 10(6) PMN were recovered as compared with 3.1 +/- 0.4 x 10(6) and 1.1 +/- 0.3 x 10(6) with increasing doses of erythromycin. Intrapulmonary bactericidal activity against S. aureus was not impaired by erythromycin.(ABSTRACT TRUNCATED AT 250 WORDS)
单羟基二十碳四烯酸和二羟基二十碳四烯酸改变兔中性粒细胞的钙稳态。
DOI：
10.1172/jci110191
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Naccache,PH;Sha'afi,RI;Borgeat,P;Goetzl,EJ
通讯作者：
Goetzl,EJ
慢性支气管炎急性发作的抗生素治疗。
影响因子：
39.2
作者：
Nicotra,MB;Rivera,M;Awe,RJ
通讯作者：
Awe,RJ