Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy.
Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy.
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DOI：
10.3389/fonc.2020.606436
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发表时间：
2020
影响因子：
4.7
通讯作者：
Chammas R
中科院分区：
文献类型：
--
作者：
Bustos SO;Antunes F;Rangel MC;Chammas R
肿瘤微环境（TME）是一个复杂的环境，其中癌细胞驻留并与不同类型的细胞，分泌因子和细胞外基质相互作用。此外，TME由几个过程形成，例如自噬。自噬是一种保守的细胞内降解途径，用于清除受损的细胞器或异常蛋白质。自噬在维持细胞内环境稳定和协调应激反应方面发挥着核心作用，在肿瘤发生中起着相反的作用。在肿瘤发展过程中，自噬还介导与癌症的几个标志相关的自噬独立功能，因此对肿瘤抑制和/或肿瘤促进机制产生几种影响。除了降解的概念之外，新的不同形式的自噬已被描述为癌症进展的调节剂，例如分泌性自噬通过货物释放实现TME中的细胞间通信。在这种情况下，通过自噬合成衰老相关分泌蛋白导致衰老表型。除了干扰肿瘤治疗反应外，自噬还参与先天性和适应性免疫信号传导。此外，最近的研究表明，自噬和上皮-间充质转化（EMT）之间存在复杂的串扰，癌细胞通过EMT获得侵袭性表型和转移潜力。因此，癌症背景下的自噬远比细胞能量感知机制更广泛和复杂。在这种情况下，我们将讨论自噬在TME和周围细胞中的关键作用，有助于癌症的发展和进展/EMT。最后，将讨论自噬过程中的潜在干预作为癌症治疗的策略。
The tumor microenvironment (TME) is a complex environment where cancer cells reside and interact with different types of cells, secreted factors, and the extracellular matrix. Additionally, TME is shaped by several processes, such as autophagy. Autophagy has emerged as a conserved intracellular degradation pathway for clearance of damaged organelles or aberrant proteins. With its central role, autophagy maintains the cellular homeostasis and orchestrates stress responses, playing opposite roles in tumorigenesis. During tumor development, autophagy also mediates autophagy-independent functions associated with several hallmarks of cancer, and therefore exerting several effects on tumor suppression and/or tumor promotion mechanisms. Beyond the concept of degradation, new different forms of autophagy have been described as modulators of cancer progression, such as secretory autophagy enabling intercellular communication in the TME by cargo release. In this context, the synthesis of senescence-associated secretory proteins by autophagy lead to a senescent phenotype. Besides disturbing tumor treatment responses, autophagy also participates in innate and adaptive immune signaling. Furthermore, recent studies have indicated intricate crosstalk between autophagy and the epithelial-mesenchymal transition (EMT), by which cancer cells obtain an invasive phenotype and metastatic potential. Thus, autophagy in the cancer context is far broader and complex than just a cell energy sensing mechanism. In this scenario, we will discuss the key roles of autophagy in the TME and surrounding cells, contributing to cancer development and progression/EMT. Finally, the potential intervention in autophagy processes as a strategy for cancer therapy will be addressed.
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影响因子：
2.9
作者：
Chen C;Liang QY;Chen HK;Wu PF;Feng ZY;Ma XM;Wu HR;Zhou GQ
通讯作者：
Zhou GQ
DOI：
10.1083/jcb.201706157
发表时间：
2018-03-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cadwell K;Debnath J
通讯作者：
Debnath J
影响因子：
5.6
作者：
Bent R;Moll L;Grabbe S;Bros M
通讯作者：
Bros M
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
DOI：
10.4161/cc.21884
发表时间：
2012-10-01
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Capparelli C;Chiavarina B;Whitaker-Menezes D;Pestell TG;Pestell RG;Hulit J;Andò S;Howell A;Martinez-Outschoorn UE;Sotgia F;Lisanti MP
通讯作者：
Lisanti MP