Systematic review of p38 mitogen-activated kinase and its functional role in reproductive tissues.
Systematic review of p38 mitogen-activated kinase and its functional role in reproductive tissues.
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DOI：
10.1111/aji.13047
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Menon R
中科院分区：
文献类型：
--
作者：
Sheller-Miller S;Richardson L;Martin L;Jin J;Menon R
氧化应激(OS)在妊娠和分娩期间子宫组织重塑中起作用。虽然p38MAPK是一种OS反应激酶，但确切的功能作用尚不清楚。因此，我们利用四个电子数据库(Web of Science，Pubmed，Medline和Cochrane)对1980年1月至2017年8月发表的关于p38 MAPK在妊娠和分娩期间生殖组织中的表达、激活和功能的文献进行了系统的综述。我们确定了418份报告，108份被选为全文评估，74份被纳入最终审查。使用母胎原代细胞或永生化细胞、组织外植体和动物模型来研究p38MAPK。蛋白质印迹最常用于报告磷酸化(活性)的p38MAPK。研究对象为人胎盘(27例)、绒毛羊膜(14例)、子宫肌层(13例)、蜕膜(8例)和宫颈(1例)。P38MAPK的功能依赖于组织和胎龄。亚型特异性几乎未见报道。P38MAPK活性是由ROS或促炎细胞因子诱导的，以促进与细胞命运、启动的子宫、成熟的宫颈以及促炎细胞因子/趋化因子的产生有关的细胞信号。35年来，关于p38MAPK在妊娠和分娩中的作用的报道很少，目前的文献不足以全面描述p38MAPK在妊娠和分娩中的机制作用。
Oxidative stress (OS) plays a role in uterine tissue remodeling during pregnancy and parturition. While p38 MAPK is an OS-response kinase, a precise functional role is unknown. Therefore, we conducted a systematic review of literature on p38 MAPK expression, activation, and function in reproductive tissues throughout pregnancy and parturition, published between January 1980-August 2017, using four electronic databases (Web of Science, Pubmed, Medline, and CoCHRANE). We identified 418 reports, 108 were selected for full text evaluation and 74 were included in final review. p38 MAPK was investigated using feto-maternal primary or immortalized cells, tissue explants, and animal models. Western blot was most commonly used to report phosphorylated (active) p38 MAPK. Human placenta (27), chorioamniotic membranes (14), myometrium (13), decidua (8) and cervix (1) were the studied tissues. p38 MAPK’s functions were tissue and gestational age dependent. Isoform specificity was hardly reported. p38 MAPK activity was induced by ROS or pro-inflammatory cytokines to promote cell signaling linked to cell fate, primed uterus, ripened cervix, and pro-inflammatory cytokine/chemokine production. In 35 years, reports on p38 MAPK’s role during pregnancy and parturition are scarce and current literature is insufficient to provide a comprehensive description of p38 MAPK’s mechanistic role during pregnancy and parturition.
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DOI：
10.1111/febs.13250
发表时间：
2015-05
期刊：
The FEBS journal
影响因子：
--
作者：
Gupta J;Nebreda AR
通讯作者：
Nebreda AR
核因子-kappa B、p38 和应激激活蛋白激酶丝裂原激活蛋白激酶信号通路调节人胎盘外植体中的促炎细胞因子和细胞凋亡，以响应氧化应激：抗氧化维生素的作用。
影响因子：
6
作者：
Cindrova-Davies, Tereza;Spasic-Boskovic, Olivera;Jauniaux, Eric;Charnock-Jones, D. Stephen;Burton, Graham J.
通讯作者：
Burton, Graham J.
影响因子：
3.6
作者：
Edey, Lydia F.;Georgiou, Hector;Johnson, Mark R.
通讯作者：
Johnson, Mark R.
影响因子：
4
作者：
Dutta, Eryn H.;Behnia, Faranak;Menon, Ramkumar
通讯作者：
Menon, Ramkumar
影响因子：
3.6
作者：
Behnia, Faranak;Peltier, Morgan R.;Menon, Ramkumar
通讯作者：
Menon, Ramkumar