Phagocytosis of microglia in the central nervous system diseases.
Phagocytosis of microglia in the central nervous system diseases.
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DOI：
10.1007/s12035-013-8620-6
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发表时间：
2014-06
影响因子：
5.1
通讯作者：
Tang, Yamei
中科院分区：
文献类型：
--
作者：
Fu, Ruying;Shen, Qingyu;Xu, Pengfei;Luo, Jin Jun;Tang, Yamei
小胶质细胞是中枢神经系统的巨噬细胞，在几乎所有神经系统疾病中迅速激活。这些活化的小胶质细胞变得高度运动，分泌炎性细胞因子，迁移到病变区域，并吞噬细胞碎片或受损的神经元。在过去的几十年中，小胶质细胞的分泌特性和趋化性已经得到了很好的研究，而对小胶质细胞的吞噬作用的研究相对较少。到目前为止，它在组织修复中是有益的还是有害的还没有明显的一致性。本文就小胶质细胞吞噬表型在阿尔茨海默病、多发性硬化、帕金森病、创伤性脑损伤、缺血性脑疾病等神经系统疾病中的作用作一综述。本文综述了各种疾病中小胶质细胞的形态特征、参与的受体和信号通路、分布沿着时空变化的变化以及影响吞噬功能的环境因素。此外，还将讨论外周循环巨噬细胞和常驻小胶质细胞对这些致病过程的贡献的比较。
Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons. During the past decades, the secretory property and chemotaxis of microglia have been well-studied, while relatively less attention has been paid to microglial phagocytosis. So far there is no obvious concordance with whether it is beneficial or detrimental in tissue repair. This review focuses on phagocytic phenotype of microglia in neurological diseases such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, traumatic brain injury, ischemic and other brain diseases. Microglial morphological characteristics, involved receptors and signaling pathways, distribution variation along with time and space changes, and environmental factors that affecting phagocytic function in each disease are reviewed. Moreover, a comparison of contributions between macrophages from peripheral circulation and the resident microglia to these pathogenic processes will also be discussed.
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DOI：
10.1097/nen.0b013e31820805b9
发表时间：
2011-02-01
影响因子：
3.2
作者：
Depboylu, Candan;Schaefer, Martin K. -H.;Hoeglinger, Guenter U.
通讯作者：
Hoeglinger, Guenter U.
影响因子：
2.5
作者：
Brown, DR
通讯作者：
Brown, DR
影响因子：
3.3
作者：
BRUCK, W;BRUCK, Y;FRIEDE, RL
通讯作者：
FRIEDE, RL
DOI：
10.1084/jem.20031237
发表时间：
2004-01-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Doyle SE;O'Connell RM;Miranda GA;Vaidya SA;Chow EK;Liu PT;Suzuki S;Suzuki N;Modlin RL;Yeh WC;Lane TF;Cheng G
通讯作者：
Cheng G
影响因子：
6.4
作者：
Collin M;McGovern N;Haniffa M
通讯作者：
Haniffa M