Human dendritic cell subsets.

Human dendritic cell subsets.
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DOI:
10.1111/imm.12117
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发表时间:
2013-09
期刊:
影响因子:
6.4
通讯作者:
Haniffa M
Haniffa M
中科院分区:
医学2区
文献类型:
--
作者:
Collin M;McGovern N;Haniffa M

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树突状细胞高度适应其呈递抗原和指导免疫应答的作用。发育研究表明,DC独立地起源于单核细胞和组织巨噬细胞。新出现的证据还表明,不同的DC亚群具有内在差异,导致免疫产生的功能专业化。比较研究现在允许许多这些特性在人类免疫学的背景下得到更充分的理解。
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.
Langerhans细胞(LC)增殖介导了新生儿发育,体内平衡和与表皮LC网络的炎症相关扩张。
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