Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma.
Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma.
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DOI：
10.3389/fphys.2018.01168
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发表时间：
2018
影响因子：
4
通讯作者：
Thomas M
中科院分区：
文献类型：
--
作者：
Mathieu E;Escribano-Vazquez U;Descamps D;Cherbuy C;Langella P;Riffault S;Remot A;Thomas M
我们对肠道微生物群的了解的提高拓宽了我们对与肠道相关的微生物的视野。这些微生物是消化和消化外健康的重要参与者和保护者，并且对人体生理至关重要。类似的重新考虑目前正在进行中，关于肺部的内源性微生物，重点从它们在感染中的作用转移到生理学上。长期以来，人们认为健康人的肺部是无菌的，而且采样困难，这推迟了肺部微生物群的发现。肺部微生物群密度低，维持少量细菌似乎是健康的关键决定因素。这篇综述旨在强调有关肺部微生物群的知识如何改变我们对肺部生理学和呼吸健康的概念。我们通过获得有关肠道微生物群和肠道生理学的知识来支持这一观点。我们描述了肺微生物群的主要特征及其对肺生理学的功能影响，特别是在健康个体中，出生后，以及哮喘。我们描述了呼吸道的一些生理特征，这些特征可能有利于生态失调微生物群的形成。肠道微生物群喂养和成熟肠上皮，并参与免疫，而肺微生物群的主要作用似乎是免疫和上皮反应性方面的定向和平衡。这意味着细菌群落的局部和远程影响可能是由病毒、过敏原或遗传缺陷引起的许多呼吸道疾病的决定性因素。最后，我们讨论了肠道和肺之间的相互联系，使这两个车厢不可分割的。
Improvements in our knowledge of the gut microbiota have broadened our vision of the microbes associated with the intestine. These microbes are essential actors and protectors of digestive and extra-digestive health and, by extension, crucial for human physiology. Similar reconsiderations are currently underway concerning the endogenous microbes of the lungs, with a shift in focus away from their involvement in infections toward a role in physiology. The discovery of the lung microbiota was delayed by the long-held view that the lungs of healthy individuals were sterile and by sampling difficulties. The lung microbiota has a low density, and the maintenance of small numbers of bacteria seems to be a critical determinant of good health. This review aims to highlight how knowledge about the lung microbiota can change our conception of lung physiology and respiratory health. We provide support for this point of view with knowledge acquired about the gut microbiota and intestinal physiology. We describe the main characteristics of the lung microbiota and its functional impact on lung physiology, particularly in healthy individuals, after birth, but also in asthma. We describe some of the physiological features of the respiratory tract potentially favoring the installation of a dysbiotic microbiota. The gut microbiota feeds and matures the intestinal epithelium and is involved in immunity, when the principal role of the lung microbiota seems to be the orientation and balance of aspects of immune and epithelial responsiveness. This implies that the local and remote effects of bacterial communities are likely to be determinant in many respiratory diseases caused by viruses, allergens or genetic deficiency. Finally, we discuss the reciprocal connections between the gut and lungs that render these two compartments inseparable.
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影响因子：
16.6
作者：
Durack J;Kimes NE;Lin DL;Rauch M;McKean M;McCauley K;Panzer AR;Mar JS;Cabana MD;Lynch SV
通讯作者：
Lynch SV
影响因子：
11.1
作者：
Bosch AATM;Levin E;van Houten MA;Hasrat R;Kalkman G;Biesbroek G;de Steenhuijsen Piters WAA;de Groot PCM;Pernet P;Keijser BJF;Sanders EAM;Bogaert D
通讯作者：
Bogaert D
影响因子：
168.9
作者：
Dickson, Robert P.;Martinez, Fernando J.;Huffnagle, Gary B.
通讯作者：
Huffnagle, Gary B.
影响因子：
4.4
作者：
Glendinning L;Wright S;Pollock J;Tennant P;Collie D;McLachlan G
通讯作者：
McLachlan G
影响因子：
12.4
作者：
Douwes, J.;Travier, N.;Pearce, N.
通讯作者：
Pearce, N.