Global genetic differentiation of complex traits shaped by natural selection in humans.
Global genetic differentiation of complex traits shaped by natural selection in humans.
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DOI：
10.1038/s41467-018-04191-y
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发表时间：
2018-05-14
影响因子：
16.6
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Guo J;Wu Y;Zhu Z;Zheng Z;Trzaskowski M;Zeng J;Robinson MR;Visscher PM;Yang J
全球人群的复杂特征存在平均差异。我们假设部分表型分化是由于自然选择。为了解决这一假设，我们使用大样本量（高达约 405,000）的数据评估了非洲、东亚和欧洲人群中十个复杂性状的性状相关 SNP 等位基因频率的差异。我们发现，与身高 ()、腰臀比 () 和精神分裂症 () 相关的 SNP 在人群中比匹配的“对照”SNP 差异显着更大，这表明这些与性状相关的 SNP 经历了自然选择。我们进一步发现，与身高 () 和精神分裂症 () 相关的 SNP 在人群中的连锁不平衡 (LD) 评分中表现出显着高于对照 SNP 的方差。我们的结果支持这样的假设：自然选择塑造了世界各地人口中复杂性状的遗传分化，例如身高和精神分裂症。人类复杂的特征和疾病通常在人群中表现出差异。在这里，作者使用来自非洲、东亚和欧洲人群的大样本数据分析了与 10 个复杂性状相关的 SNP，并发现了自然选择形成的全球人群之间显着的遗传差异。
There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height (), waist-to-hip ratio (), and schizophrenia () are significantly more differentiated among populations than matched “control” SNPs, suggesting that these trait-associated SNPs have undergone natural selection. We further find that SNPs associated with height () and schizophrenia () show significantly higher variance in linkage disequilibrium (LD) scores across populations than control SNPs. Our results support the hypothesis that natural selection has shaped the genetic differentiation of complex traits, such as height and schizophrenia, among worldwide populations. Human complex traits and disorders often show differentiation among populations. Here, the authors analyze SNPs associated with 10 complex traits using data of large sample size from African, East Asian and European populations, and find significant genetic differentiation among global populations shaped by natural selection.
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