Ebola Virus Disease in Children, Sierra Leone, 2014-2015.

Ebola Virus Disease in Children, Sierra Leone, 2014-2015.
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DOI:
10.3201/eid2210.160579
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发表时间:
2016-10
影响因子:
11.8
通讯作者:
Yeung S
Yeung S
中科院分区:
医学2区
文献类型:
--
作者:
Fitzgerald F;Naveed A;Wing K;Gbessay M;Ross JC;Checchi F;Youkee D;Jalloh MB;Baion D;Mustapha A;Jah H;Lako S;Oza S;Boufkhed S;Feury R;Bielicki JA;Gibb DM;Klein N;Sahr F;Yeung S

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儿童迅速死亡,一半以上在埃博拉收容所中死亡,然后才被转移到治疗室。对于儿童埃博拉病毒病的潜在可改变因素知之甚少。我们对 2014 年至 2015 年塞拉利昂西部地区 11 个埃博拉收容所收治的 13 岁以下儿童进行了回顾性队列研究,以确定影响结果的因素。主要结局是死亡或转移到埃博拉治疗中心后出院。所有 309 名 2 天至 12 岁的埃博拉病毒阳性儿童均被纳入; 282 人 (91%) 可获得结果。病死率为 57%,其中 55% 的死亡发生在埃博拉病毒收容单位。血液检查结果显示低血糖和肝/肾功能障碍。死亡发生得很快(平均入院后 3 天),并且与年龄较小和腹泻有关。尽管对多个来源的信息进行了三角测量,但数据可用性有限,我们没有发现对死亡有重大影响的可改变因素。在未来的埃博拉病毒病流行中,可靠、快速的数据收集对于确定儿童干预措施的有效性至关重要。
Children died rapidly, more than half in Ebola holding units before transfer to treatment units. Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014–2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus–positive children 2 days–12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.
塞拉利昂的埃博拉反应:对儿童的影响。
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