Ebola Virus Disease in Children, Sierra Leone, 2014-2015.
Ebola Virus Disease in Children, Sierra Leone, 2014-2015.
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DOI:
10.3201/eid2210.160579
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发表时间:
2016-10
影响因子:
11.8
通讯作者:
Yeung S
中科院分区:
文献类型:
--
作者:
Fitzgerald F;Naveed A;Wing K;Gbessay M;Ross JC;Checchi F;Youkee D;Jalloh MB;Baion D;Mustapha A;Jah H;Lako S;Oza S;Boufkhed S;Feury R;Bielicki JA;Gibb DM;Klein N;Sahr F;Yeung S
Children died rapidly, more than half in Ebola holding units before transfer to treatment units. Little is known about potentially modifiable factors in Ebola virus disease in children. We undertook a retrospective cohort study of children <13 years old admitted to 11 Ebola holding units in the Western Area, Sierra Leone, during 2014–2015 to identify factors affecting outcome. Primary outcome was death or discharge after transfer to Ebola treatment centers. All 309 Ebola virus–positive children 2 days–12 years old were included; outcomes were available for 282 (91%). Case-fatality was 57%, and 55% of deaths occurred in Ebola holding units. Blood test results showed hypoglycemia and hepatic/renal dysfunction. Death occurred swiftly (median 3 days after admission) and was associated with younger age and diarrhea. Despite triangulation of information from multiple sources, data availability was limited, and we identified no modifiable factors substantially affecting death. In future Ebola virus disease epidemics, robust, rapid data collection is vital to determine effectiveness of interventions for children.
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DOI:
10.1016/j.jinf.2016.04.016
发表时间:
2016-07-05
期刊:
The Journal of infection
影响因子:
--
作者:
Fitzgerald F;Awonuga W;Shah T;Youkee D
通讯作者:
Youkee D
DOI:
10.1056/nejmoa1411100
发表时间:
2014-10-16
期刊:
The New England journal of medicine
影响因子:
--
作者:
WHO Ebola Response Team;Aylward B;Barboza P;Bawo L;Bertherat E;Bilivogui P;Blake I;Brennan R;Briand S;Chakauya JM;Chitala K;Conteh RM;Cori A;Croisier A;Dangou JM;Diallo B;Donnelly CA;Dye C;Eckmanns T;Ferguson NM;Formenty P;Fuhrer C;Fukuda K;Garske T;Gasasira A;Gbanyan S;Graaff P;Heleze E;Jambai A;Jombart T;Kasolo F;Kadiobo AM;Keita S;Kertesz D;Koné M;Lane C;Markoff J;Massaquoi M;Mills H;Mulba JM;Musa E;Myhre J;Nasidi A;Nilles E;Nouvellet P;Nshimirimana D;Nuttall I;Nyenswah T;Olu O;Pendergast S;Perea W;Polonsky J;Riley S;Ronveaux O;Sakoba K;Santhana Gopala Krishnan R;Senga M;Shuaib F;Van Kerkhove MD;Vaz R;Wijekoon Kannangarage N;Yoti Z
通讯作者:
Yoti Z
影响因子:
168.9
作者:
Broadhurst, Mara Jana;Kelly, John Daniel;Pollock, Nira R.
通讯作者:
Pollock, Nira R.
影响因子:
158.5
作者:
Gignoux, Etienne;Azman, Andrew S.;Ciglenecki, Iza
通讯作者:
Ciglenecki, Iza
影响因子:
8.4
作者:
Li, Jin;Duan, Hui-Juan;Wang, Fu-Sheng
通讯作者:
Wang, Fu-Sheng