Pathogenesis of Bronchopulmonary Dysplasia: Role of Oxidative Stress from 'Omics' Studies.
Pathogenesis of Bronchopulmonary Dysplasia: Role of Oxidative Stress from 'Omics' Studies.
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DOI：
10.3390/antiox11122380
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发表时间：
2022-12-01
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影响因子：
--
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中科院分区：
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支气管肺发育不良（BPD）仍然是早产儿最常见的呼吸系统并发症，因为年龄较小的婴儿存活超过了新生儿期。氧化应激（OS）在BPD发病机制中起关键作用的认识至少自20世纪80年代以来已被广泛接受。在这篇文章中，我们研究了OS和遗传调控之间的相互作用，并回顾了与BPD中OS相关的“组学”数据。来自动物模型（主要是高氧肺损伤模型）和人类研究的数据。表观遗传学和转录组学分析已经证明了与OS相关的几个基因在模拟BPD的鼠模型中以及在有BPD发展风险的早产儿和患有已确定的肺部疾病的婴儿中差异表达。抗氧化酶的遗传调节的改变是这些研究中的一个共同主题。来自代谢组学和蛋白质组学的数据也证明了OS相关途径在BPD中的潜在参与。许多研究的局限性包括难以从人类患者获得及时和适当的样品。更多的“组学”研究可以进一步了解OS在BPD发病机制中的作用，这可能有助于预防和及时诊断，并有助于靶向治疗的发展。
Bronchopulmonary dysplasia (BPD) remains the most common respiratory complication of prematurity as younger and smaller infants are surviving beyond the immediate neonatal period. The recognition that oxidative stress (OS) plays a key role in BPD pathogenesis has been widely accepted since at least the 1980s. In this article, we examine the interplay between OS and genetic regulation and review ‘omics’ data related to OS in BPD. Data from animal models (largely models of hyperoxic lung injury) and from human studies are presented. Epigenetic and transcriptomic analyses have demonstrated several genes related to OS to be differentially expressed in murine models that mimic BPD as well as in premature infants at risk of BPD development and infants with established lung disease. Alterations in the genetic regulation of antioxidant enzymes is a common theme in these studies. Data from metabolomics and proteomics have also demonstrated the potential involvement of OS-related pathways in BPD. A limitation of many studies includes the difficulty of obtaining timely and appropriate samples from human patients. Additional ‘omics’ studies could further our understanding of the role of OS in BPD pathogenesis, which may prove beneficial for prevention and timely diagnosis, and aid in the development of targeted therapies.
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影响因子：
5.1
作者：
Ambalavanan, Namasivayam;Cotten, C. Michael;Page, Grier P.;Carlo, Waldemar A.;Murray, Jeffrey C.;Bhattacharya, Soumyaroop;Mariani, Thomas J.;Cuna, Alain C.;Faye-Petersen, Ona M.;Kelly, David;Higgins, Rosemary D.
通讯作者：
Higgins, Rosemary D.
影响因子：
3.7
作者：
Baraldi E;Giordano G;Stocchero M;Moschino L;Zaramella P;Tran MR;Carraro S;Romero R;Gervasi MT
通讯作者：
Gervasi MT
影响因子：
8
作者：
Banks, BA;Ischiropoulos, H;Ballard, RA
通讯作者：
Ballard, RA
DOI：
10.1152/ajplung.00200.2014
发表时间：
2014-10-01
影响因子：
4.9
作者：
Bhattacharya, Soumyaroop;Zhou, Zhongyang;O'Reilly, Michael A.
通讯作者：
O'Reilly, Michael A.
影响因子：
7.4
作者：
Cho, HY;Reddy, SP;Kleeberger, SR
通讯作者：
Kleeberger, SR