Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins.
Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins.
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青春期对体重指数的遗传和环境影响：芬兰双胞胎的一项前瞻性研究。
DOI：
10.1038/ijo.2009.51
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发表时间：
2009-05
影响因子：
4.9
通讯作者：
Silventoinen, K.
中科院分区：
文献类型：
--
作者：
Lajunen, H-R;Kaprio, J.;Keski-Rahkonen, A.;Rose, R. J.;Pulkkinen, L.;Rissanen, A.;Silventoinen, K.
研究影响青春期体重指数 (BMI) 和 BMI 表型相关性的遗传和环境因素。前瞻性、基于人群的双胞胎队列研究。我们对出生于 1983 年至 1987 年的 2413 对芬兰同卵双胞胎、同性和异性异卵双胞胎进行了双胞胎建模，并在 11-12、14 和 17 岁时通过自我报告问卷进行了评估。 11-12岁和14岁男孩和女孩的BMI遗传力估计为0.58-0.69，17岁男孩为0.83，女孩为0.74。在 11-12 岁和 14 岁的男孩和女孩中，兄弟姐妹共同的环境影响为 0.15-0.24，但在 17 岁时不再明显。独特的环境影响为 0.15–0.23。加性遗传因素解释了青春期 90-96% 的 BMI 表型相关性，而独特的环境因素则解释了其余部分。共同环境对 BMI 表型相关性没有影响。青春期时遗传对 BMI 的影响很大，这主要解释了整个青春期 BMI 表型的相关性。常见的环境因素对青春期早期的体重指数有影响，但这种影响到青春期后期就会消失。
To study genetic and environmental factors affecting body mass index (BMI) and BMI phenotypic correlations across adolescence. Prospective, population-based, twin cohort study. We used twin modeling in 2413 monozygotic and same-sex and opposite-sex dizygotic Finnish twin pairs born in 1983–1987 and assessed by self-report questionnaires at 11–12, 14, and 17 years. Heritability of BMI was estimated to be 0.58–0.69 among 11–12- and 14-year-old boys and girls, 0.83 among 17-year-old boys and 0.74 among girls. Common environmental effects shared by siblings were 0.15–0.24 among 11–12- and 14-year-old boys and girls but no longer discernible at 17 y. Unique environmental effects were 0.15–0.23. Additive genetic factors explained 90–96% of the BMI phenotypic correlations across adolescence, whereas unique environmental factors explained the rest. Common environment had no effect on BMI phenotypic correlations. The genetic contribution to BMI is strong during adolescence, and it mainly explains BMI phenotypic correlations across adolescence. Common environmental factors have an effect on BMI during early adolescence, but that effect disappears by late adolescence.
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影响因子：
2.9
作者：
DECASTRO, JM
通讯作者：
DECASTRO, JM
影响因子：
2.9
作者：
Keskitalo, Kaisu;Silventoinen, Karri;Kaprio, Jaakko
通讯作者：
Kaprio, Jaakko
影响因子：
5.5
作者：
Nelson, Melissa C.;Gordon-Larsen, Penny;Popkin, Barry M.
通讯作者：
Popkin, Barry M.
影响因子：
4.9
作者：
Koeppen-Schomerus, G;Wardle, J;Plomin, R
通讯作者：
Plomin, R
影响因子：
2.6
作者：
Eriksson, M;Rasmussen, F;Tynelius, P
通讯作者：
Tynelius, P