Dissociated multimodal hubs and seizures in temporal lobe epilepsy.
Dissociated multimodal hubs and seizures in temporal lobe epilepsy.
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DOI：
10.1002/acn3.173
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发表时间：
2015-04
影响因子：
5.3
通讯作者：
Stufflebeam, Steven M.
中科院分区：
文献类型：
--
作者：
Douw, Linda;DeSalvo, Matthew N.;Tanaka, Naoaki;Cole, Andrew J.;Liu, Hesheng;Reinsberger, Claus;Stufflebeam, Steven M.
Brain connectivity at rest is altered in temporal lobe epilepsy (TLE), particularly in “hub” areas such as the posterior default mode network (DMN). Although both functional and anatomical connectivity are disturbed in TLE, the relationships between measures as well as to seizure frequency remain unclear. We aim to clarify these associations using connectivity measures specifically sensitive to hubs. Connectivity between 1000 cortical surface parcels was determined in 49 TLE patients and 23 controls with diffusion and resting-state functional magnetic resonance imaging. Two types of hub connectivity were investigated across multiple brain modules (the DMN, motor system, etcetera): (1) within-module connectivity (a measure of local importance that assesses a parcel's communication level within its own subnetwork) and (2) between-module connectivity (a measure that assesses connections across multiple modules). In TLE patients, there was lower overall functional integrity of the DMN as well as an increase in posterior hub connections with other modules. Anatomical between-module connectivity was globally decreased. Higher DMN disintegration (DD) coincided with higher anatomical between-module connectivity, whereas both were associated with increased seizure frequency. DD related to seizure frequency through mediating effects of anatomical connectivity, but seizure frequency also correlated with anatomical connectivity through DD, indicating a complex interaction between multimodal networks and symptoms. We provide evidence for dissociated anatomical and functional hub connectivity in TLE. Moreover, shifts in functional hub connections from within to outside the DMN, an overall loss of integrative anatomical communication, and the interaction between the two increase seizure frequency.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
Stam CJ
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
3.4
作者：
Czarnecki, Antonny;Tscherter, Anne;Streit, Juerg
通讯作者：
Streit, Juerg
影响因子：
19.7
作者：
DeSalvo, Matthew N.;Douw, Linda;Stufflebeam, Steven M.
通讯作者：
Stufflebeam, Steven M.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y