Using tetracyclines to treat osteoporotic/osteopenic bone loss: from the basic science laboratory to the clinic.
Using tetracyclines to treat osteoporotic/osteopenic bone loss: from the basic science laboratory to the clinic.
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DOI：
10.1016/j.phrs.2010.10.006
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发表时间：
2011-02
影响因子：
9.3
通讯作者：
Golub, Lorne M.
中科院分区：
文献类型：
--
作者：
Payne, Jeffrey B.;Golub, Lorne M.
关键词：
牙周炎（以牙槽骨丢失为特征的进行性炎症性疾病，是全世界牙齿脱落的主要原因）与全身性骨质疏松症及其较轻微的骨质减少有关。四环素凭借其非抗菌促合成代谢和抗分解代谢特性，是同时治疗这些局部和全身疾病的极好的候选药物。本文回顾了基础科学和转化研究，这些研究导致了一项针对患有牙周炎和全身（骨骼）骨质减少的绝经后妇女的关键多中心随机临床试验。该试验的目的主要是检查亚抗菌剂量的多西环素 (SDD) 是否可以减少与牙周炎相关的进行性牙槽（口腔）骨丢失，其次是检查 SDD 是否可以减少同一受试者的全身性骨丢失。本文描述了该临床试验的功效和安全性结果，并概述了使用这种有前景的新颖方法来管理口腔和全身骨质流失的未来方向。
Periodontitis (progressive inflammatory disease characterized by alveolar bone loss, a major cause of tooth loss worldwide) is associated with both systemic osteoporosis and its milder form, osteopenia. Tetracyclines, by virtue of their non-antimicrobial proanabolic and anti-catabolic properties, are excellent candidate pharmaceuticals to simultaneously treat these local and systemic disorders. This paper reviews the foundational basic science and translational research which lead to a pivotal multicenter randomized clinical trial in postmenopausal women with both periodontitis and systemic (skeletal) osteopenia. This trial was designed primarily to examine whether subantimicrobial dose doxycycline (SDD) could reduce progressive alveolar (oral) bone loss associated with periodontitis and, secondarily, whether SDD could reduce systemic bone loss in the same subjects. This paper describes the efficacy and safety findings from this clinical trial and also outlines future directions using this promising and novel approach to manage both oral and systemic bone loss.
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影响因子：
4.3
作者：
Crout, RJ;Lee, HM;Golub, LM
通讯作者：
Golub, LM
DOI：
10.1161/01.atv.0000121571.78696.dc
发表时间：
2004-04-01
影响因子：
8.7
作者：
Brown, DL;Desai, KK;Golub, LM
通讯作者：
Golub, LM
影响因子：
3.5
作者：
Lee, HM;Golub, LM;Crout, R
通讯作者：
Crout, R
影响因子：
6.7
作者：
GOODSON, JM;TANNER, ACR;SOCRANSKY, SS
通讯作者：
SOCRANSKY, SS
影响因子：
45.3
作者：
Dezube, BJ;Krown, SE;Aboulafia, DM
通讯作者：
Aboulafia, DM