Anomalous dynamics of the endoplasmic reticulum network.

Anomalous dynamics of the endoplasmic reticulum network.
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内质网网络的异常动力学

DOI:
10.1103/physreve.98.012406
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发表时间:
2018
期刊:
Physical review. E
影响因子:
--
通讯作者:
M. Weiss
M. Weiss
中科院分区:
--
文献类型:
--
作者:
K. Speckner;L. Stadler ;M. Weiss

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真核细胞中的大部分内质网(ER)被组织成动态网络,其片段通过三通连接。在这里,我们表明,ER连接移动subdiffusively与分数布朗运动的签名和强烈的依赖于细胞骨架的完整性:时间平均均方位移尺度为未处理的细胞内和破坏微管时,连续的步骤是在这两种情况下的相关性。我们解释我们的观察认为ER结移动像单体(半)柔性聚合物段沉浸在粘弹性环境中。我们还报告说,ER网络有一个非平凡的分形维数在介观尺度上,我们提供的证据表明,细胞器的动力学是由分形。
Large portions of the endoplasmic reticulum (ER) in eukaryotic cells are organized as dynamic networks whose segments are connected by three-way junctions. Here we show that ER junctions move subdiffusively with signatures of fractional Brownian motion and a strong dependence on the cytoskeleton's integrity: The time-averaged mean square displacement scales aswithin untreated cells andwhen disrupting microtubules, with successive steps being anticorrelated in both cases. We explain our observations by considering ER junctions to move like monomers in (semi)flexible polymer segments immersed in a viscoelastic environment. We also report that ER networks have a nontrivial fractal dimensionon mesoscopic scales and we provide evidence that the organelle's dynamics is governed by fractons.
DOI: --
发表时间: 2018
影响因子: --
作者:
Csilla Ferencz;Gernot Guigas;Andreas Veres;Brigitte Neumann;O. Stemmann;M. Weiss
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DOI: 10.1016/j.bpj.2012.03.062
发表时间: 2012-06-06
影响因子: 3.4
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影响因子: 9.2
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发表时间: 2010-07
期刊: Physical review. E, Statistical, nonlinear, and soft matter physics
影响因子: --
作者:
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