Reactive lysis: the complement-mediated lysis of unsensitized cells. I. The characterization of the indicator factor and its identification as C7.
Reactive lysis: the complement-mediated lysis of unsensitized cells. I. The characterization of the indicator factor and its identification as C7.
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反应性裂解:补体介导的未敏化细胞的裂解。 I.指标因子的表征及其标识为C7。
DOI:
10.1084/jem.131.4.629
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发表时间:
1970-04-01
影响因子:
15.3
通讯作者:
LACHMANN, PJ
中科院分区:
文献类型:
--
作者:
THOMPSON, RA;LACHMANN, PJ
This paper describes the characteristics of the indicator factor (I) which takes part in reactive hemolysis and its identification as the seventh component of complement. I was shown to be a beta globulin with a sediment coefficient of 5.7S and a molecular weight of about 140,000. Experiments on the depletion of I activity with anti-I antiserum or with activated R euglobulin showed that I was a late acting complement component necessary for the lysis of cells after the EAC142 stage. Complement component analysis of purified I fractions excluded all known components except C7. The physicochemical characteristics of I are compatible with published data on C7. The method of quantitation described represents a convenient method of testing for C7.
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DOI:
10.1084/jem.125.1.1
发表时间:
1967-01-01
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
Nilsson UR;Müller-Eberhard HJ
通讯作者:
Müller-Eberhard HJ
影响因子:
56.9
作者:
HADDING, U;MULLEREB.HJ
通讯作者:
MULLEREB.HJ
DOI:
10.1016/0019-2791(66)90292-8
发表时间:
1966-01-01
期刊:
IMMUNOCHEMISTRY
影响因子:
--
作者:
NELSON, RA;JENSEN, J;TAMURA, N
通讯作者:
TAMURA, N
影响因子:
15.3
作者:
LACHMANN, PJ;THOMPSON, RA
通讯作者:
THOMPSON, RA
DOI:
10.1016/0019-2791(65)90004-2
发表时间:
1965-09-01
期刊:
Immunochemistry
影响因子:
--
作者:
Mancini, G;Carbonara, A O;Heremans, J F
通讯作者:
Heremans, J F