The association between overall survival of prostate cancer patients and hypertension, hyperglycemia, and overweight in Southern China: a prospective cohort study
The association between overall survival of prostate cancer patients and hypertension, hyperglycemia, and overweight in Southern China: a prospective cohort study
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中国南方前列腺癌患者总生存率与高血压、高血糖和超重之间的关系：一项前瞻性队列研究
DOI：
10.1007/s00432-013-1407-3
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发表时间：
2013-02
影响因子：
3.6
通讯作者：
Jiang, Hao-wen
中科院分区：
文献类型：
--
作者：
Liu, Jun;Ding, Guan-xiong;Ding, Qiang;Jiang, Hao-wen
目的高血压、高血糖和超重被认为与前列腺癌的发展和预后有关。本研究旨在探讨既往高血压、高血糖、超重与去雄激素治疗(ADT)的PCa患者总生存期(OS)的关系。方法对2003年1月至2012年8月在本院接受ADT治疗的323例PCa患者的临床资料进行分析。通过Kaplan-Meier方法分别分析OS与高血压、高血糖或超重的关系。临床病理特征在不同组间的分布采用Fisher精确检验或卡方检验。结果在本研究期间，23名男性(7.12%)失访。在43个月(范围3-119个月)的中位随访期间，122例死亡(40.67%)得到确认。同时患有高血压和超重的男性5年OS率(28.57%)显著低于对照组(48.33%，P=0.024)。也略低于单纯高血压(50.00%，P=0.0.095)或超重(55.56%，P=0.088)。同时患有高血糖和超重的男性生存时间明显短于对照组(P=0.037)。除超重患者PSA值>20 ng/mL的比例(65.38%)明显低于对照组(84.95%，P=0.026)外，其余各组患者的临床资料分布基本一致。结论既往高血压、高血糖、超重与PCa患者预后不良有关。同时患有高血压和超重的男性，或同时患有高血糖和超重的男性，存活时间显著缩短。
PurposeHypertension, hyperglycemia, and overweight are considered associated with the development and prognosis of prostate cancer (PCa). This study is aimed at investigating the association between pre-existing hypertension, hyperglycemia, and overweight and the overall survival (OS) of PCa patients receiving androgen deprivation therapy (ADT).MethodsWe studied the clinical data of 323 patients of PCa receiving ADT in our hospital from January 2003 to August 2012 aged 50–91. The association between OS and hypertension, hyperglycemia, or overweight, both separately and together, was analyzed via Kaplan–Meier method. The distributions of clinicopathological features among groups were evaluated using Fisher’s exact or chi-square test.Results23 men (7.12 %) were lost to follow-up during this study. During a median follow-up for 43 months (range 3–119 months), 122 deaths (40.67 %) were confirmed. The five-year OS rate of men with both hypertension and overweight (28.57 %) was significantly lower than that of control group (48.33 %,P= 0.024). It was also moderately lower than that of men just with hypertension (50.00 %,P= 0.095) or overweight (55.56 %,P= 0.088). Men with both hyperglycemia and overweight had significantly shorter survival time than control group (P= 0.037). The distributions of clinical information were similar among all the groups except that overweight patients had a lower proportion of PSA level over 20 ng/mL (65.38 %) than control group (84.95 %,P= 0.026).ConclusionsPre-existing hypertension, hyperglycemia, and overweight were associated with poor prognosis of PCa patients. Men with both hypertension and overweight, or with both hyperglycemia and overweight had significantly shorter survival time.
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DOI：
10.1016/j.juro.2009.01.047
发表时间：
2009-05
期刊：
The Journal of urology
影响因子：
--
作者：
Saylor PJ;Smith MR
通讯作者：
Smith MR
影响因子：
158.5
作者：
Yang, Wenying;Lu, Juming;He, Jiang
通讯作者：
He, Jiang
影响因子：
3.8
作者：
Rodriguez, Carmen;Freedland, Stephen J.;Calle, Eugenia E.
通讯作者：
Calle, Eugenia E.
影响因子：
6.6
作者：
Saylor, Philip J.;Smith, Matthew R.
通讯作者：
Smith, Matthew R.
影响因子：
6.2
作者：
Wright, Margaret E.;Chang, Shih-Chen;Leitzmann, Michael F.
通讯作者：
Leitzmann, Michael F.