Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism.
Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism.
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DOI：
10.1038/s41598-017-11325-7
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发表时间：
2017-09-11
影响因子：
4.6
通讯作者：
Papadopoulos V
中科院分区：
文献类型：
--
作者：
Campioli E;Lee S;Lau M;Marques L;Papadopoulos V
2002年，增塑剂1，2-环己烷二羧酸酯(DINCH)被引入欧洲市场，作为干扰内分泌的邻苯二甲酸酯的替代品。我们发现，从孕14天到分娩，子宫内暴露于DINCH会影响大鼠的生殖器官生理，并在出生后60天降低循环睾酮水平，表明DINCH对睾丸间质细胞有长期影响。在代谢方面，动物表现出随机升高的血清葡萄糖浓度，与葡萄糖利用受损无关。对血清中肝脏标志物的分析显示了肝脏效应；例如，降低了胆红素水平和白蛋白/球蛋白比率。在出生后第200天，暴露的子代出现随机的睾丸萎缩，其他生殖参数的变化有限。总而言之，接触DINCH似乎直接影响间质细胞功能，可能导致睾丸过早衰老和肝脏代谢能力受损。这些影响可能会随着生理年龄的增长而减弱。
In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduced in the European market as a substitute for endocrine-disrupting phthalates. We found that in utero exposure of rats to DINCH from gestational day 14 until parturition affected reproductive organ physiology and reduced circulating testosterone levels at post-natal day 60, indicating a long-term effect on Leydig cells of the testis. Metabolically, animals exhibited randomly increased serum glucose concentrations not associated with impaired glucose utilization. Analysis of liver markers in the serum showed a hepatic effect; e.g. reduced bilirubin levels and albumin/globulin ratio. At post-natal day 200, random appearance of testicular atrophy was noted in exposed offspring, and limited changes in other reproductive parameters were observed. In conclusion, DINCH exposure appears to directly affect Leydig cell function, likely causing premature aging of the testes and impaired liver metabolic capacity. These effects might be attenuated with physiologic aging.
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DOI：
10.1083/jcb.200409107
发表时间：
2004-12-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Davidoff MS;Middendorff R;Enikolopov G;Riethmacher D;Holstein AF;Müller D
通讯作者：
Müller D
影响因子：
8.3
作者：
Campioli, Enrico;Duong, Tam B.;Papadopoulos, Vassilios
通讯作者：
Papadopoulos, Vassilios
影响因子：
3.4
作者：
Hedger, MP
通讯作者：
Hedger, MP
影响因子：
20.1
作者：
Chawla A
通讯作者：
Chawla A
影响因子：
3.2
作者：
Harris, Sean;Shubin, Sara Pacheco;Wegner, Susanna;Van Ness, Kirk;Green, Foad;Hong, Sung Woo;Faustman, Elaine M.
通讯作者：
Faustman, Elaine M.