Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease.
Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease.
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围围心肌病：全球努力寻找罕见且鲜为人知的疾病的原因和治愈。
DOI：
10.1007/s12551-022-00930-0
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发表时间：
2022-03
影响因子：
--
通讯作者：
Dos Remedios C
中科院分区：
文献类型：
--
作者：
Li A;Campbell K;Lal S;Ge Y;Keogh A;Macdonald PS;Lau P;Lai J;Linke WA;Van der Velden J;Field A;Martinac B;Grosser M;Dos Remedios C
In this review, we present our current understanding of peripartum cardiomyopathy (PPCM) based on reports of the incidence, diagnosis and current treatment options. We summarise opinions on whether PPCM is triggered by vascular and/or hormonal causes and examine the influence of comorbidities such as preeclampsia. Two articles published in 2021 strongly support the hypothesis that PPCM may be a familial disease. Using large cohorts of PPCM patients, they summarised the available genomic DNA sequence data that are expressed in human cardiomyocytes. While PPCM is considered a disease predominately affecting the left ventricle, there are data to suggest that some cases also involve right ventricular failure. Finally, we conclude that there is sufficient evidence to warrant an RNAseq investigation and that this would be most informative if performed at the cardiomyocytes level rather than analysing genomic DNA from the peripheral circulation. Given the rarity of PPCM, the combined resources of international human heart tissue biobanks have assembled 30 ventricular tissue samples from PPCM patients, and we are actively seeking to enlarge this patient base by collaborating with human heart tissue banks and research laboratories who would like to join this endeavour.
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DOI：
10.1073/pnas.1809540115
发表时间：
2018-08-28
影响因子：
11.1
作者：
Anderson, Robert L.;Trivedi, Darshan V.;Spudich, James A.
通讯作者：
Spudich, James A.
影响因子：
8.9
作者：
Fett, JD;Christie, LG;Murphy, JG
通讯作者：
Murphy, JG
影响因子：
2.6
作者：
Bouabdallaoui N;Demondion P;Maréchaux S;Varnous S;Lebreton G;Mouquet F;Leprince P
通讯作者：
Leprince P
影响因子：
6.1
作者：
Gloecklhofer, Christina R.;Steinfurt, Johannes;Odening, Katja E.
通讯作者：
Odening, Katja E.
影响因子：
--
作者：
Dos Remedios, Cris;Gilmour, Darcy
通讯作者：
Gilmour, Darcy