CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues.
CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues.
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CCL27是皮肤和粘膜组织免疫稳态的重要调节剂。
DOI：
10.1016/j.isci.2022.104426
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发表时间：
2022-06-17
期刊：
影响因子：
5.8
通讯作者：
Xiong, Na
中科院分区：
文献类型：
--
作者：
Davila, Micha L.;Xu, Ming;Huang, Chengyu;Gaddes, Erin R.;Winter, Levi;Cantorna, Margherita T.;Wang, Yong;Xiong, Na
大量的免疫细胞存在于屏障组织中。了解这些细胞的调节可以了解它们在组织稳态和炎症中的作用。在这里，我们报告说，趋化因子CCL 27是建立居民淋巴细胞和屏障组织中的免疫稳态的关键。CCL 27表达与正常皮肤和毛囊发育相关，不依赖于细菌刺激，表明趋化因子的稳态作用。因此，在CCL 27敲除小鼠的皮肤中，表达CCL 27的同源受体CCR 10的T细胞的存在减少和定位失调。此外，CCL 27基因敲除小鼠在咪喹莫特诱导的银屑病模型中具有过度反应性皮肤炎症反应。除了皮肤之外，CCL 27敲除小鼠的肺部和生殖道中的CCR 10 + T细胞浸润增加，后者也表现出自发性炎症。我们的研究结果表明，CCL 27是跨屏障组织的免疫稳态的关键。CCL 27-KO小鼠在皮肤驻留Treg和Teff细胞的建立中受损咪喹莫特处理的CCL 27-KO小鼠具有增加的皮肤IL-17+ T细胞和炎症CCL 27-KO小鼠在肺和生殖道中具有受损的T细胞稳态生物科学;免疫学;免疫应答
Abundant immune cells reside in barrier tissues. Understanding the regulation of these cells can yield insights on their roles in tissue homeostasis and inflammation. Here, we report that the chemokine CCL27 is critical for establishment of resident lymphocytes and immune homeostasis in barrier tissues. CCL27 expression is associated with normal skin and hair follicle development independent of commensal bacterial stimulation, indicative of a homeostatic role for the chemokine. Accordingly, in the skin of CCL27-knockout mice, there is a reduced presence and dysregulated localization of T cells that express CCR10, the cognate receptor to CCL27. Besides, CCL27-knockout mice have overreactive skin inflammatory responses in an imiquimod-induced model of psoriasis. Beyond the skin, CCL27-knockout mice have increased infiltration of CCR10+ T cells into lungs and reproductive tracts, the latter of which also exhibit spontaneous inflammation. Our findings demonstrate that CCL27 is critical for immune homeostasis across barrier tissues. The creation of a line of total CCL27-knockout (KO) mice CCL27-KO mice are impaired in establishment of skin-resident Treg and Teff cells Imiquimod-treated CCL27-KO mice have increased skin IL-17+ T cells and inflammation CCL27-KO mice have impaired T cell homeostasis in lungs and reproductive tracts Biological sciences; Immunology; Immune response
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影响因子：
6.5
作者：
Cochez, Perrine M.;Michiels, Camille;Dumoutier, Laure
通讯作者：
Dumoutier, Laure
影响因子：
7.3
作者：
Casciano, Fabio;Diani, Marco;Reali, Eva
通讯作者：
Reali, Eva
DOI：
10.1006/bbrc.1999.0507
发表时间：
1999-05-19
影响因子：
3.1
作者：
Hromas, R;Broxmeyer, HE;Hou, YH
通讯作者：
Hou, YH
DOI：
10.1073/pnas.0912943107
发表时间：
2010-04-20
影响因子：
11.1
作者：
Jiang, Xiaodong;Campbell, James J.;Kupper, Thomas S.
通讯作者：
Kupper, Thomas S.
影响因子：
6.5
作者：
Hotz, Claire;Boniotto, Michele;Hue, Sophie
通讯作者：
Hue, Sophie