Regulation of actin assembly by PI(4,5)P2 and other inositol phospholipids: An update on possible mechanisms.
Regulation of actin assembly by PI(4,5)P2 and other inositol phospholipids: An update on possible mechanisms.
复制标题
PI（4,5）P2和其他肌醇磷脂对肌动蛋白组装的调节：可能的机制更新。
DOI：
10.1016/j.bbrc.2018.07.155
复制
发表时间：
2018-11-25
影响因子：
3.1
通讯作者：
Radhakrishnan R
中科院分区：
文献类型：
--
作者：
Janmey PA;Bucki R;Radhakrishnan R
肌动蛋白细胞骨架动力学依赖于肌动蛋白丝形成的严格调控，肌动蛋白丝从细胞内的单体池形成，然后它们相互连接或与细胞膜连接，然后它们解聚成新的肌动蛋白单体池。肌动蛋白的持续重塑是许多细胞功能所必需的，这在很大程度上是由肌动蛋白结合蛋白协调的，肌动蛋白结合蛋白对肌动蛋白的亲和力被肌醇磷脂改变，最突出的是PI(4,5)P2（磷脂酰肌醇4,5二磷酸）。PI(4,5)P2合成和水解的动力学，其在脂质双分子层内的横向分布，以及PI(4,5)P2和其他信号的同步检测，都在确定特定PI(4,5)P2调节蛋白何时何地失活或激活以发挥其对肌动蛋白细胞骨架的作用方面发挥作用。这篇综述总结了一系列已经开发的模型，这些模型基于实验和计算研究的结合来解释PI(4,5)P2如何在细胞复杂的化学和结构环境中发挥作用。
Actin cytoskeleton dynamics depend on a tight regulation of actin filament formation from an intracellular pool of monomers, followed by their linkage to each other or to cell membranes, followed by their depolymerization into a fresh pool of actin monomers. The ubiquitous requirement for continuous actin remodeling that is necessary for many cellular functions is orchestrated in large part by actin binding proteins whose affinity for actin is altered by inositol phospholipids, most prominently PI(4,5)P2 (phosphatidylinositol 4,5bisphosphate). The kinetics of PI(4,5)P2 synthesis and hydrolysis, its lateral distribution within the lipid bilayer, and coincident detection of PI(4,5)P2 and another signal, all play a role in determining when and where a particular PI(4,5)P2-regulated proteins is inactivated or activated to exert its effect on the actin cytoskeleton. This review summarizes a range of models that have been developed to explain how PI(4,5)P2 might function in the complex chemical and structural environment of the cell based on a combination of experiment and computational studies.
登录
查看更多内容
影响因子：
19
作者：
Diz-Muñoz A;Fletcher DA;Weiner OD
通讯作者：
Weiner OD
影响因子：
3.4
作者：
Dwivedi, Mridula;Winter, Roland
通讯作者：
Winter, Roland
DOI：
10.1073/pnas.1305286110
发表时间：
2013-04-30
影响因子：
11.1
作者：
Gallop，Jennifer L.;Walrant，Astrid;Kirschner，Marc W.
通讯作者：
Kirschner，Marc W.
影响因子：
2.9
作者：
Bucki, R;Giraud, F;Sulpice, JC
通讯作者：
Sulpice, JC
影响因子：
4.8
作者：
Chen, Xiaodong;Khajeh, Jahan Ali;Bu, Zimei
通讯作者：
Bu, Zimei