Use the force: membrane tension as an organizer of cell shape and motility.

Use the force: membrane tension as an organizer of cell shape and motility.
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DOI:
10.1016/j.tcb.2012.09.006
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发表时间:
2013-02
影响因子:
19
通讯作者:
Weiner OD
Weiner OD
中科院分区:
生物学1区
文献类型:
--
作者:
Diz-Muñoz A;Fletcher DA;Weiner OD

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许多涉及形状变化的细胞现象受到质膜内在变形能力的影响。质膜远不是一个被动的参与者,现在已知的物理,以及生物化学,影响细胞过程,从囊泡运输到肌动蛋白组装。在这里,我们审查目前的理解如何在质膜张力的变化调节细胞的形状和运动,以及细胞如何感觉质膜张力。
Many cell phenomena that involve shape changes are affected by the intrinsic deformability of the plasma membrane. Far from being a passive participant, the plasma membrane is now known to physically, as well as biochemically, influence cell processes ranging from vesicle trafficking to actin assembly. Here we review current understanding of how changes in plasma membrane tension regulate cell shape and movement as well as how cells sense plasma membrane tension.
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