Genomic Consequences of Long-Term Population Decline in Brown Eared Pheasant.
Genomic Consequences of Long-Term Population Decline in Brown Eared Pheasant.
复制标题
褐马鸡数量长期下降的基因组后果
DOI：
10.1093/molbev/msaa213
复制
发表时间：
2021-01-04
影响因子：
10.7
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Wang P;Burley JT;Liu Y;Chang J;Chen D;Lu Q;Li SH;Zhou X;Edwards S;Zhang Z
群体遗传学理论和经验证据表明，有害等位基因可以在小群体中被清除。然而，这一观点仍然存在争议。当野生种群数量持续下降时，自然选择是否有足够的力量清除有害的突变，目前还不清楚。野鸡是一种陆生鸟类，由于人为干扰和开发，面临着长期灭绝的危险。然而，用于保护管理和规划的基因组学资源很少。在此，我们分析了中国现存的3个褐耳雉（Crossoptilon mantchuricum）分离种群的基因组数据。我们发现，由于过去10万年的持续下降，满洲C.具有较低的全基因组多样性和收缩的有效种群规模。我们比较了C. mantchuricum的全基因组变异与其密切相关的姐妹物种蓝耳雉（C. auritum）的全基因组变异，后者的保护关注程度较低。在所有的manchuricum基因组中都存在有害的遗传后果，包括纯合序列的延长、连锁不平衡衰减的缓慢速率、过度的功能突变丧失以及主要组织相容性复合体区域适应性遗传多样性的丧失。据我们所知，这项研究是第一次对这种濒危野鸡物种进行全面的保护基因组分析。此外，我们证明了自然选择可能不足以清除长期衰退的野生种群中的有害突变。本研究的发现可以促进濒危物种的保护规划，并有助于恢复其种群规模。
Population genetic theory and empirical evidence indicate that deleterious alleles can be purged in small populations. However, this viewpoint remains controversial. It is unclear whether natural selection is powerful enough to purge deleterious mutations when wild populations continue to decline. Pheasants are terrestrial birds facing a long-term risk of extinction as a result of anthropogenic perturbations and exploitation. Nevertheless, there are scant genomics resources available for conservation management and planning. Here, we analyzed comparative population genomic data for the three extant isolated populations of Brown eared pheasant (Crossoptilon mantchuricum) in China. We showed that C. mantchuricum has low genome-wide diversity and a contracting effective population size because of persistent declines over the past 100,000 years. We compared genome-wide variation in C. mantchuricum with that of its closely related sister species, the Blue eared pheasant (C. auritum) for which the conservation concern is low. There were detrimental genetic consequences across all C. mantchuricum genomes including extended runs of homozygous sequences, slow rates of linkage disequilibrium decay, excessive loss-of-function mutations, and loss of adaptive genetic diversity at the major histocompatibility complex region. To the best of our knowledge, this study is the first to perform a comprehensive conservation genomic analysis on this threatened pheasant species. Moreover, we demonstrated that natural selection may not suffice to purge deleterious mutations in wild populations undergoing long-term decline. The findings of this study could facilitate conservation planning for threatened species and help recover their population size.
登录
查看更多内容
影响因子：
3
作者：
Korneliussen TS;Albrechtsen A;Nielsen R
通讯作者：
Nielsen R
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
影响因子：
3
作者：
Alexander DH;Lange K
通讯作者：
Lange K
影响因子：
4.9
作者：
Kozma, Radoslav;Melsted, Pall;Hoglund, Jacob
通讯作者：
Hoglund, Jacob
影响因子：
3.3
作者：
LANDE, R;SCHEMSKE, DW
通讯作者：
SCHEMSKE, DW