Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats.
Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats.
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DOI：
10.1016/j.neulet.2008.07.074
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发表时间：
2008-10-10
影响因子：
2.5
通讯作者：
Goldberg SR
中科院分区：
文献类型：
--
作者：
Le Foll B;Wertheim CE;Goldberg SR
神经化学研究表明，巴氯芬，GABAB受体激动剂，可能是有用的尼古丁依赖的治疗。然而，它选择性地减少尼古丁滥用相关行为影响的能力仍然存在疑问。我们评估了0.1至3 mg/kg巴氯芬剂量范围对雄性Sprague道利大鼠尼古丁诱导的条件性位置偏好（CPP）、尼古丁辨别、自发活动和食物强化行为的影响。高剂量巴氯芬（3 mg/kg）完全消除食物强化反应，并显着降低自发活动。低剂量的巴氯芬没有尼古丁样的歧视作用，在大鼠训练区分0.4毫克/公斤的尼古丁从盐水下的固定比例10的时间表的食物交付。较低剂量的巴氯芬也没有降低尼古丁训练剂量的辨别刺激效应，也没有显著改变尼古丁辨别的剂量-反应曲线。用3 mg/kg高剂量巴氯芬处理的大鼠未表达尼古丁诱导的CPP。这些实验，沿着先前的报告，即巴氯芬可以减少静脉内尼古丁自我给药行为，证实了巴氯芬作为戒烟工具的潜在效用。
Neurochemical studies suggest that baclofen, an agonist at GABAB receptors, may be useful for treatment of nicotine dependence. However, its ability to selectively reduce nicotine’s abuse-related behavioral effects remains in question. We assessed effects of baclofen doses ranging from 0.1 to 3 mg/kg on nicotine-induced conditioned place preferences (CPP), nicotine discrimination, locomotor activity and food-reinforced behavior in male Sprague Dawley rats. The high dose of baclofen (3 mg/kg) totally eliminated food-reinforced responding and significantly decreased locomotor activity. Lower doses of baclofen did not have nicotine-like discriminative effects in rats trained to discriminate 0.4 mg/kg nicotine from saline under a fixed-ratio 10 schedule of food delivery. Lower doses of baclofen also did not reduce discriminative-stimulus effects of the training dose of nicotine and did not significantly shift the dose-response curve for nicotine discrimination. Rats treated with the high 3 mg/kg dose of baclofen did not express nicotine-induced CPP. These experiments, along with previous reports that baclofen can reduce intravenous nicotine self-administration behavior, confirm the potential utility of baclofen as a tool for smoking cessation.
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影响因子：
3.6
作者：
FUDALA, PJ;TEOH, KW;IWAMOTO, ET
通讯作者：
IWAMOTO, ET
影响因子：
2.8
作者：
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2.3
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4.7
作者：
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影响因子：
3.4
作者：
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