Inflammation and oxidative stress as mediators of the impacts of environmental exposures on human pregnancy: Evidence from oxylipins.
Inflammation and oxidative stress as mediators of the impacts of environmental exposures on human pregnancy: Evidence from oxylipins.
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DOI：
10.1016/j.pharmthera.2022.108181
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发表时间：
2022-11
影响因子：
13.5
通讯作者：
Ferguson KK
中科院分区：
文献类型：
--
作者：
Welch BM;McNell EE;Edin ML;Ferguson KK
炎症和氧化应激在健康和病理性妊娠中起主要作用。环境暴露于化学污染物可能会对孕妇和胎儿的健康产生不利影响，因为这些关键的炎症和氧化应激过程会失调。氧脂素是生物活性脂质，在调节炎症中发挥重要作用，越来越多的证据表明其在妊娠中的重要性。氧脂素的生物合成生产需要多不饱和脂肪酸的氧化，这可以通过几种充分表征的酶和非酶途径发生。本文综述了关于妊娠期氧脂素产生的流行病学证据的科学现状及其与1）关键妊娠结局和2）环境暴露的关系。我们在PubMed中检索了在妊娠或分娩期间测量一种或多种氧脂平分析物的妊娠研究。我们评估了氧脂平与三类不良妊娠结局的关系，包括先兆子痫、早产和胎儿生长受限，以及沿着几类环境污染物。大多数研究评价了一到两种氧脂素，其中大多数集中在氧化应激的非酶促过程中产生的氧脂素。然而，越来越多的最近的研究已经利用技术进步来描述大量从不同的生物合成途径产生的氧脂素。虽然文献表明，强有力的证据表明，通过非酶途径产生的氧脂素与妊娠结局和环境暴露有关，但酶促产生的氧脂素的证据表明，生物合成途径之间的关联可能不同。沿着总结这些证据，我们回顾了有希望的治疗方案，以调节氧脂素的生产，并提供了一套建议，为未来的流行病学研究在这些研究领域。需要进一步的证据来提高我们对氧脂素如何作为环境污染物对妊娠结局不利影响的关键生物介质的理解。
Inflammation and oxidative stress play major roles in healthy and pathological pregnancy. Environmental exposure to chemical pollutants may adversely affect maternal and fetal health in pregnancy by dysregulating these critical underlying processes of inflammation and oxidative stress. Oxylipins are bioactive lipids that play a major role in regulating inflammation and increasing lines of evidence point towards an importance in pregnancy. The biosynthetic production of oxylipins requires oxygenation of polyunsaturated fatty acids, which can occur through several well-characterized enzymatic and nonenzymatic pathways. This review describes the state of the science of epidemiologic evidence on oxylipin production in pregnancy and its association with 1) key pregnancy outcomes and 2) environmental exposures. We searched PubMed for studies of pregnancy that measured one or more oxylipin analytes during pregnancy or delivery. We evaluated oxylipin associations with three categories of adverse pregnancy outcomes, including preeclampsia, preterm birth, and fetal growth restriction, along with several categories of environmental pollutants. The majority of studies evaluated one to two oxylipins, most of which focused on oxylipins produced from nonenzymatic processes of oxidative stress. However, an increasing number of recent studies have leveraged technological advancements to profile a large number of oxylipins produced from distinct biosynthetic pathways. Although the literature indicated robust evidence that oxylipins produced via nonenzymatic pathways are associated with pregnancy outcomes and environmental exposures, evidence for enzymatically produced oxylipins showed that associations may differ between biosynthetic pathways. Along with summarizing this evidence, we review promising therapeutic options to regulate oxylipin production and provide a set of recommendations for future epidemiologic studies in these research areas. Further evidence is needed to improve our understanding of how oxylipins may act as key biological mediators for the adverse effects of environmental pollutants on pregnancy outcomes.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
影响因子：
64.5
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
通讯作者：
Davis MM
影响因子：
168.9
作者：
Chappell, LC;Seed, PT;Poston, L
通讯作者：
Poston, L
DOI：
10.1136/bmj.h217
发表时间：
2015-02-05
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Alfirevic Z;Keeney E;Dowswell T;Welton NJ;Dias S;Jones LV;Navaratnam K;Caldwell DM
通讯作者：
Caldwell DM
影响因子：
7.2
作者：
通讯作者：
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