Variation in the human immune system is largely driven by non-heritable influences.
Variation in the human immune system is largely driven by non-heritable influences.
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DOI：
10.1016/j.cell.2014.12.020
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发表时间：
2015-01-15
期刊：
影响因子：
64.5
通讯作者：
Davis MM
中科院分区：
文献类型：
--
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
个体之间的免疫学参数存在相当大的异质性，但其来源很大程度上未知。为了评估遗传因素与非遗传因素的相对贡献，我们对 210 名 8-82 岁的健康双胞胎进行了系统级分析。我们测量了 204 个不同的参数，包括细胞群频率、细胞因子反应和血清蛋白，发现其中 77% 受非遗传影响主导（方差 > 50%），58% 几乎完全由非遗传影响决定（方差 > 80%）。此外，其中一些参数随着年龄的增长而变得更加可变，表明环境暴露的累积影响。同样，季节性流感疫苗接种的血清学反应也很大程度上由非遗传因素决定，可能是由于反复接触不同毒株所致。最后，在巨细胞病毒感染不一致的同卵双胞胎中，超过一半的参数受到影响。这些结果凸显了健康个体免疫系统在很大程度上具有反应性和适应性。
There is considerable heterogeneity in immunological parameters between individuals, but its sources are largely unknown. To assess the relative contribution of heritable versus non-heritable factors, we have performed a systems-level analysis of 210 healthy twins between 8–82 years of age. We measured 204 different parameters, including cell population frequencies, cytokine responses, and serum proteins, and found that 77% of these are dominated (> 50% of variance) and 58% almost completely determined (> 80% of variance) by non-heritable influences. In addition, some of these parameters become more variable with age, suggesting the cumulative influence of environmental exposure. Similarly, the serological responses to seasonal influenza vaccination are also determined largely by non-heritable factors, likely due to repeated exposure to different strains. Lastly, in MZ twins discordant for cytomegalovirus infection, over half of all parameters are affected. These results highlight the largely reactive and adaptive nature of the immune system in healthy individuals.
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影响因子：
0.9
作者：
Krasnow, Ruth E.;Jack, Lisa M.;Swan, Gary E.
通讯作者：
Swan, Gary E.
DOI：
10.1073/pnas.0500398102
发表时间：
2005-07-26
影响因子：
11.1
作者：
Fraga, MF;Ballestar, E;Esteller, M
通讯作者：
Esteller, M
影响因子：
30.8
作者：
Gregersen, Peter K.;Amos, Chistopher I.;Lee, Annette T.;Lu, Yue;Remmers, Elaine F.;Kastner, Daniel L.;Seldin, Michael F.;Criswell, Lindsey A.;Plenge, Robert M.;Holers, V. Michael;Mikuls, Ted R.;Sokka, Tuulikki;Moreland, Larry W.;Bridges, S. Louis, Jr.;Xie, Gang;Begovich, Ann B.;Siminovitch, Katherine A.
通讯作者：
Siminovitch, Katherine A.
DOI：
10.1111/j.1749-6632.2010.05834.x
发表时间：
2010-01-01
期刊：
YEAR IN HUMAN AND MEDICAL GENETICS: NEW TRENDS IN MENDELIAN GENETICS
影响因子：
--
作者：
Alcais, Alexandre;Quintana-Murci, Lluis;Casanova, Jean-Laurent
通讯作者：
Casanova, Jean-Laurent
影响因子：
100.3
作者：
Dorshkind, Kenneth;Montecino-Rodriguez, Encarnacion;Signer, Robert A. J.
通讯作者：
Signer, Robert A. J.