Malaria parasite density and detailed qualitative microscopy enhances large-scale profiling of infection endemicity in Nigeria.
Malaria parasite density and detailed qualitative microscopy enhances large-scale profiling of infection endemicity in Nigeria.
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DOI：
10.1038/s41598-023-27535-1
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发表时间：
2023-01-28
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
随着全球减少疟疾的进展停滞不前，需要进一步分析流行病学，特别是在负担最重的国家。国家调查大多分析了感染率，但很少有关于寄生虫密度和不同发育形式的大规模数据。在全球负担最重的国家尼日利亚，在2018年全国人口与健康调查中对5岁以下儿童进行了血液载玻片显微镜检查，此前报告了寄生虫患病率。在目前的研究中，报告和分析了疟疾寄生虫密度测量的7783名儿童在全国6个地缘政治区域内的36个州的抽样。分析了无性和有性阶段，以及不同疟疾寄生虫的感染情况。在尼日利亚的所有州，感染者体内的平均无性寄生虫密度与社区感染率之间呈正相关（斯皮尔曼的rho = 0.39，P = 0.02）。无性寄生虫密度在北方地理区域最高（几何平均值> 2000 μL−1），这进一步证明了许多地区的感染负担异常高。每个州的性寄生虫流行率与无性寄生虫流行率高度相关（斯皮尔曼rho = 0.70，P < 0.001），尽管性寄生虫密度较低（所有区域的几何平均值< 100 μL−1）。婴儿的寄生虫密度低于1岁以上的儿童，但男女儿童之间没有差异。绝大多数感染是恶性疟原虫，其具有较高的无性密度，但较低的性寄生虫密度比三日疟原虫或卵形疟原虫单一感染。然而，混合种感染具有最高的无性寄生虫密度。建议今后在高负担国家进行大规模调查，测量寄生虫密度以及发育阶段和种类，以提高疟疾流行病学和跟踪未来变化的质量。
With global progress towards malaria reduction stalling, further analysis of epidemiology is required, particularly in countries with the highest burden. National surveys have mostly analysed infection prevalence, while large-scale data on parasite density and different developmental forms rarely available. In Nigeria, the country with the largest burden globally, blood slide microscopy of children up to 5 years of age was conducted in the 2018 National Demographic and Health Survey, and parasite prevalence previously reported. In the current study, malaria parasite density measurements are reported and analysed for 7783 of the children sampled across the 36 states within the six geopolitical zones of the country. Asexual and sexual stages, and infections with different malaria parasite species are analysed. Across all states of Nigeria, there was a positive correlation between mean asexual parasite density within infected individuals and prevalence of infection in the community (Spearman’s rho = 0.39, P = 0.02). Asexual parasite densities were highest in the northern geopolitical zones (geometric means > 2000 μL−1), extending the evidence of exceptionally high infection burden in many areas. Sexual parasite prevalence in each state was highly correlated with asexual parasite prevalence (Spearman’s rho = 0.70, P < 0.001), although sexual parasite densities were low (geometric means < 100 μL−1 in all zones). Infants had lower parasite densities than children above 1 year of age, but there were no differences between male and female children. Most infections were of P. falciparum, which had higher asexual densities but lower sexual parasite densities than P. malariae or P. ovale mono-infections. However, mixed species infections had the highest asexual parasite densities. It is recommended that future large surveys in high burden countries measure parasite densities as well as developmental stages and species, to improve the quality of malaria epidemiology and tracking of future changes.
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影响因子：
56.3
作者：
Hay, Simon I.;Smith, David L.;Snow, Robert W.
通讯作者：
Snow, Robert W.
影响因子：
17.1
作者：
Joice R;Nilsson SK;Montgomery J;Dankwa S;Egan E;Morahan B;Seydel KB;Bertuccini L;Alano P;Williamson KC;Duraisingh MT;Taylor TE;Milner DA;Marti M
通讯作者：
Marti M
影响因子：
3
作者：
D'Alessandro U;Ubben D;Hamed K;Ceesay SJ;Okebe J;Taal M;Lama EK;Keita M;Koivogui L;Nahum A;Bojang K;Sonko AA;Lalya HF;Brabin B
通讯作者：
Brabin B
DOI：
10.1016/s2666-5247(21)00009-4
发表时间：
2021-04
期刊：
The Lancet. Microbe
影响因子：
--
作者：
Akala HM;Watson OJ;Mitei KK;Juma DW;Verity R;Ingasia LA;Opot BH;Okoth RO;Chemwor GC;Juma JA;Mwakio EW;Brazeau N;Cheruiyot AC;Yeda RA;Maraka MN;Okello CO;Kateete DP;Managbanag JR;Andagalu B;Ogutu BR;Kamau E
通讯作者：
Kamau E
影响因子：
3.7
作者：
Bruce, Marian C.;Macheso, Allan;Molyneux, Malcolm E.
通讯作者：
Molyneux, Malcolm E.