Malaria in infants aged less than six months - is it an area of unmet medical need?
Malaria in infants aged less than six months - is it an area of unmet medical need?
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DOI：
10.1186/1475-2875-11-400
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发表时间：
2012-12-02
期刊：
影响因子：
3
通讯作者：
Brabin B
中科院分区：
文献类型：
--
作者：
D'Alessandro U;Ubben D;Hamed K;Ceesay SJ;Okebe J;Taal M;Lama EK;Keita M;Koivogui L;Nahum A;Bojang K;Sonko AA;Lalya HF;Brabin B
尽管包括母体抗体在内的若干因素提供了保护，但疟疾给幼儿造成的负担可能比以前想象的要高。患有先天性或新生儿疟疾的婴儿可能与年龄较大的儿童有不同的临床表现，由于临床表现重叠，诊断可能与其他新生儿疾病混淆。此外，关于在幼儿中使用青蒿素类复方疗法的资料很少。有必要更准确地估计6个月以下婴儿的寄生虫流行率和临床疟疾发病率，并更好地描述风险因素、药代动力学特征、现有抗疟疾治疗的安全性和有效性，以便为这一人群制定循证治疗指南。
Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought. Infants with congenital or neonatal malaria may have a different clinical presentation than older children, and diagnosis may be confused with other neonatal diseases due to an overlap of clinical manifestations. In addition, there is little information on the use of artemisinin-based combination therapy in young infants. There is the need for a more accurate estimate of the parasite prevalence and the incidence of clinical malaria in infants under 6 months old, as well as a better characterization of risk factors, pharmacokinetic profiles, safety and efficacy of currently available anti-malarial treatments, in order to develop evidence-based treatment guidelines for this population.
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影响因子：
3.3
作者：
Falade, Catherine;Mokuolu, Olugbenga;Callahan, Michael V.
通讯作者：
Callahan, Michael V.
DOI：
10.1179/136485910x12607012373993
发表时间：
2010-03-01
影响因子：
--
作者：
Ishengoma, D. R. S.;Derua, Y. A.;Magesa, S. M.
通讯作者：
Magesa, S. M.
影响因子：
168.9
作者：
Aponte, John J.;Schellenberg, David;Menendez, Clara
通讯作者：
Menendez, Clara
影响因子：
--
作者：
AKINDELE, JA;SOWUNMI, A;ABOHWEYERE, AEJ
通讯作者：
ABOHWEYERE, AEJ
影响因子：
1.6
作者：
Fischer, PR
通讯作者：
Fischer, PR