Monofloral Triadica Cochinchinensis Honey Polyphenols Improve Alcohol-Induced Liver Disease by Regulating the Gut Microbiota of Mice.
Monofloral Triadica Cochinchinensis Honey Polyphenols Improve Alcohol-Induced Liver Disease by Regulating the Gut Microbiota of Mice.
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单花Triadica Cochinchinensis蜂蜜多酚通过调节小鼠肠道微生物群改善酒精引起的肝病
DOI：
10.3389/fimmu.2021.673903
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发表时间：
2021
影响因子：
7.3
通讯作者：
Ning F
中科院分区：
文献类型：
--
作者：
Luo L;Zhang J;Liu M;Qiu S;Yi S;Yu W;Liu T;Huang X;Ning F
从药用植物中生产的蜂蜜对人类健康有很大的希望。越来越多的证据表明，肠道微生物群在酒精摄入后的肝脏病理学中起着重要作用。本研究的目的是鉴定三叠叶蜂蜜（TCH）的多酚成分，并研究蜂蜜多酚对酒精性肝损伤小鼠肠道微生物的调节作用及对酒精性肝病的改善作用。为此，共鉴定了190种化合物，其中27种通过超高效液相色谱-四极杆/飞行时间质谱联用（UPLC-Q/TOF-MS）进行了定量，我们成功地建立了小鼠酒精性肝损伤模型。结果表明，TCH多酚能显著恢复酒精染毒小鼠的ALT和AST水平，TCH干预能显著改善酒精染毒小鼠肝组织的病理改变。此外，TCH处理后观察到厚壁菌门/拟杆菌门显著减少。此外，ATP结合盒（ABC）转运蛋白的KEGG途径，双组分系统和氨基酸的生物合成富集TCH干预8周后差异表达的基因。我们的研究结果可能对TCH作为一种功能性食品成分的使用具有重要意义，对酒精诱导的肝病具有潜在的治疗作用。
Honey produced from medicinal plants holds great promise for human health. Increasing evidence suggests that the gut microbiota plays an important role in liver pathology after alcohol intake. The aim of this study was to identify the polyphenol composition of triadica cochinchinensis honey (TCH), and to study the potential effect of honey polyphenols on the regulation of gut microbes in mice with alcohol-induced liver injury and the improvement of alcohol-induced liver disease. For these purposes, a total of 190 compounds were identified and 27 of them were quantified by ultraperformance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and we successfully established a mouse model of alcohol-induced liver injury. The results show that TCH polyphenols can significantly restore the levels of ALT and AST, and TCH intervention can significantly improve the pathological changes of liver tissue in alcohol-exposed mice. Additionally, a significant decrease was observed in Firmicutes/Bacteroidetes after TCH treatment. Moreover, KEGG pathways of ATP-binding cassette (ABC) transporters, two-component system and biosynthesis of amino acids enriched the most differentially expressed genes after TCH intervention for 8 weeks. Our results may have important implications for the use of TCH as a functional food component with potential therapeutic utility against alcohol-induced liver disease.
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影响因子：
15.5
作者：
Dubinkina VB;Tyakht AV;Odintsova VY;Yarygin KS;Kovarsky BA;Pavlenko AV;Ischenko DS;Popenko AS;Alexeev DG;Taraskina AY;Nasyrova RF;Krupitsky EM;Shalikiani NV;Bakulin IG;Shcherbakov PL;Skorodumova LO;Larin AK;Kostryukova ES;Abdulkhakov RA;Abdulkhakov SR;Malanin SY;Ismagilova RK;Grigoryeva TV;Ilina EN;Govorun VM
通讯作者：
Govorun VM
影响因子：
6.1
作者：
Wang, Kai;Wan, Zhengrui;Xue, Xiaofeng
通讯作者：
Xue, Xiaofeng
酒精性肝病：发病机制和新的治疗靶点。
影响因子：
29.4
作者：
Gao B;Bataller R
通讯作者：
Bataller R
影响因子：
14.8
作者：
通讯作者：
--
影响因子：
81.5
作者：
Seitz, Helmut K.;Bataller, Ramon;Tsukamoto, Hidekazu
通讯作者：
Tsukamoto, Hidekazu