Association of Preoperative Serum Levels of CEA and CA15-3 with Molecular Subtypes of Breast Cancer.
Association of Preoperative Serum Levels of CEA and CA15-3 with Molecular Subtypes of Breast Cancer.
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DOI：
10.1155/2021/5529106
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Yang Q
中科院分区：
文献类型：
--
作者：
Zhao W;Li X;Wang W;Chen B;Wang L;Zhang N;Wang Z;Yang Q
分子亚型被用作靶向治疗和重要预后因素的指导。本研究旨在探讨血清CEA、CA 15 -3和CA 125水平与乳腺癌临床病理特征的关系，以寻找乳腺癌的预后指标，为乳腺癌的靶向治疗提供依据。 本研究分析了961例乳腺癌患者术前血清CEA、CA 15 -3和CA 125水平及其分子亚型。CEA、CA 15 -3和CA 125分别使用5 ng/ml、25 U/ml和35 U/ml的截止值。采用χ2检验、Fisher精确沿着检验及Logistic多元回归分析，探讨血清CEA、CA 15 -3、CA 125水平与分子亚型及相关因素的相关性。 48例（4.99%）乳腺癌患者血清CEA、54例（5.62%）乳腺癌患者血清CA 15 -3、55例（5.72%）血清CA 125浓度升高。单因素分析显示CEA（p < 0.01）和CA 15 -3（p < 0.05）水平与乳腺癌的分子分型有关。此外，肿瘤体积较大（分别为p < 0.01、p < 0.0001和p < 0.05）的患者沿着淋巴结转移（分别为p < 0.05、p = 0.0001和p < 0.05），CEA、CA 15 -3和CA 125水平升高的比率较高。Her-2阳性状态与CEA水平升高有显著相关性（P < 0.01）。多因素分析进一步表明分子亚型是影响CEA和CA 15 -3水平的独立因素。此外，Her-2状态与CEA水平显着且独立相关。 术前血清CEA和CA 15 -3水平与乳腺癌分子亚型独立相关。CEA和CA 15 -3可提高乳腺癌患者的预后预测，并为选择特异性治疗提供信息。Her-2表达与CEA水平之间的关系有待于进一步的生物学分析。
Molecular subtypes are employed as a guide for targeted treatment and important prognostic factors. This study focused on investigating the association of serum levels of CEA, CA15-3, and CA125 with clinicopathological characteristics of breast cancer to find prognostic markers for breast cancer and provide precise targeted therapy. In this study, 961 breast cancer patients with preoperative serum levels of CEA, CA15-3, and CA125 and molecular subtypes were analyzed. Cut-off values of 5 ng/ml, 25 U/ml, and 35 U/ml were used for CEA, CA15-3, and CA125, respectively. The χ2 test and Fisher exact test along with logistic multivariate regression analysis were performed for investigating the correlation of CEA, CA15-3, and CA125 serum levels with molecular subtypes and associated factors. An increase in the serum concentrations of CEA, CA15-3, and CA125 was discovered in 48 (4.99%), 54 (5.62%), and 55 (5.72%) breast cancer patients, respectively. Univariate analysis demonstrated that the levels of CEA (p < 0.01) and CA15-3 (p < 0.05) were significantly linked with molecular types of breast cancer. Moreover, patients having larger tumor size (p < 0.01, p < 0.0001, and p < 0.05, respectively) along with nodal metastasis (p < 0.05, p = 0.0001, and p < 0.05, respectively) exhibited higher rates of elevated CEA, CA15-3, and CA125 levels. Status of Her-2 positive (p < 0.01) had a significant connection with elevated CEA levels. Multivariate analysis further indicated that molecular subtypes were independent factors associated with CEA and CA15-3 levels. Also, Her-2 status was significantly and independently related to CEA levels. Preoperative serum levels of CEA and CA15-3 were independently associated with molecular subtypes of breast cancer. CEA and CA15-3 might improve the prognostic prediction for patients with breast cancer and inform the selection of specific therapies. A further biological analysis is needed for investigating the relationship between Her-2 expression and CEA levels.
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影响因子：
5.5
作者：
Lei S;Zheng R;Zhang S;Chen R;Wang S;Sun K;Zeng H;Wei W;He J
通讯作者：
He J
DOI：
10.1016/s1470-2045(21)00288-6
发表时间：
2021-08
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Early Breast Cancer Trialists’ Collaborative group (EBCTCG)
通讯作者：
Early Breast Cancer Trialists’ Collaborative group (EBCTCG)
乳腺癌患者术前5种血清肿瘤标志物与病理特征的关系
影响因子：
2.7
作者：
Lian, Mingjian;Zhang, Cuixia;Hong, Guolin
通讯作者：
Hong, Guolin
影响因子：
9.3
作者：
Molina, Rafael;Auge, Jose M.;Velasco, Martin
通讯作者：
Velasco, Martin
影响因子：
7.3
作者：
De Cock L;Heylen J;Wildiers A;Punie K;Smeets A;Weltens C;Neven P;Billen J;Laenen A;Wildiers H
通讯作者：
Wildiers H