Circulating Metabolites and Lipids Are Associated to Diabetic Retinopathy in Individuals With Type 1 Diabetes.
Circulating Metabolites and Lipids Are Associated to Diabetic Retinopathy in Individuals With Type 1 Diabetes.
复制标题
循环代谢物和脂质与 1 型糖尿病患者的糖尿病视网膜病变相关。
作者：
Curovic VR;Suvitaival T;Mattila I;Ahonen L;Trošt K;Theilade S;Hansen TW;Legido-Quigley C;Rossing P
基于OMIC的方法可以提供与糖尿病视网膜病变（DR）相关的新标记物。我们研究了与1型糖尿病DR相关的代谢物和脂质的广泛组学小组。在648例1型糖尿病患者中，使用二维气相色谱-飞行时间质谱法进行代谢组学分析，并使用超高效液相色谱四重飞行时间质谱法进行脂质组学分析。受试者分为无DR、轻度非增殖性DR（NPDR）、中度NPDR、增殖性DR和增殖性DR伴纤维化。终点为DR的任何进展、DR的发作和从轻度到重度DR的进展，这些进展是从标准门诊护理中跟踪并使用考克斯模型进行研究的。该队列包括648名参与者，平均年龄为54.4 ± 12.8岁，55.5%为男性，随访时间为5.1-5.5年。在横断面上，2，4-二羟基丁酸（DHBA）、3，4-DHBA、核糖酸、核糖醇和甘油三酯50：1和50：2与DR分期显著相关（P < 0.042）。纵向上，校正后，较高的3，4-DHBA是DR进展的风险标志物（n = 133）（P = 0.033）。我们证明了多种代谢产物与1型糖尿病中更高级别的DR呈正相关，而几种甘油三酯呈负相关。此外，较高的3，4-DHBA是DR进展的独立风险标志物;然而，需要确认。
Omics-based methods may provide new markers associated to diabetic retinopathy (DR). We investigated a wide omics panel of metabolites and lipids related to DR in type 1 diabetes. Metabolomic analyses were performed using two-dimensional gas chromatography with time-of-flight mass spectrometry and lipidomic analyses using an ultra-high-performance liquid chromatography quadruple time-of-flight mass spectrometry method in 648 individuals with type 1 diabetes. Subjects were subdivided into no DR, mild nonproliferative DR (NPDR), moderate NPDR, proliferative DR, and proliferative DR with fibrosis. End points were any progression of DR, onset of DR, and progression from mild to severe DR tracked from standard ambulatory care and investigated using Cox models. The cohort consisted of 648 participants aged a mean of 54.4 ± 12.8 years, 55.5% were men, and follow-up was 5.1–5.5 years. Cross-sectionally, 2,4-dihydroxybutyric acid (DHBA), 3,4-DHBA, ribonic acid, ribitol, and the triglycerides 50:1 and 50:2 significantly correlated (P < 0.042) to DR stage. Longitudinally, higher 3,4-DHBA was a risk marker for progression of DR (n = 133) after adjustment (P = 0.033). We demonstrated multiple metabolites being positively correlated to a higher grade of DR in type 1 diabetes and several triglycerides being negatively correlated. Furthermore, higher 3,4-DHBA was an independent risk marker for progression of DR; however, confirmation is required.
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DOI：
10.1056/nejmoa1001288
发表时间：
2010-07-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
ACCORD Study Group;ACCORD Eye Study Group;Chew EY;Ambrosius WT;Davis MD;Danis RP;Gangaputra S;Greven CM;Hubbard L;Esser BA;Lovato JF;Perdue LH;Goff DC Jr;Cushman WC;Ginsberg HN;Elam MB;Genuth S;Gerstein HC;Schubart U;Fine LJ
通讯作者：
Fine LJ
影响因子：
7.7
作者：
CLEMENTS, RS;REYNERTSON, R
通讯作者：
REYNERTSON, R
影响因子：
7.4
作者：
Castillo, Sandra;Mattila, Ismo;Hyotylainen, Tuulia
通讯作者：
Hyotylainen, Tuulia
DOI：
10.1900/rds.2015.12.159
发表时间：
2015-03-01
期刊：
The review of diabetic studies : RDS
影响因子：
--
作者：
Jenkins, Alicia J;Joglekar, Mugdha V;Januszewski, Andrzej S
通讯作者：
Januszewski, Andrzej S
影响因子：
168.9
作者：
Keech, A. C.;Mitchell, P.;Colman, P. G.
通讯作者：
Colman, P. G.