Molecular and cellular approaches to memory allocation in neural circuits.
Molecular and cellular approaches to memory allocation in neural circuits.
复制标题
DOI：
10.1126/science.1174519
复制
发表时间：
2009-10-16
期刊：
影响因子：
--
通讯作者：
Balaji J
中科院分区：
文献类型：
--
作者：
Silva AJ;Zhou Y;Rogerson T;Shobe J;Balaji J
尽管记忆分配是计算机科学中一个活跃的研究课题，但人们对大脑如何在神经回路中分配信息知之甚少。关于特定类型的记忆如何与大脑的不同部位联系，以及这些区域的神经元如何处理和存储信息，有大量的文献。然而，直到最近，在学习过程中，决定神经回路中特定细胞和突触（而不是它们的邻居）如何被招募的机制还很少受到关注。最近的研究表明，记忆的分配不是随机的，而是特定的机制来调节信息在神经回路中的存储位置。对行为动物的神经元进行标记、成像、激活和失活的新方法有望彻底改变包括记忆分配在内的脑回路研究。这些研究的结果可能会对计算机科学以及对记忆及其紊乱的理解产生相当大的影响。
Although memory allocation is a subject of active research in computer science, little is known about how the brain allocates information within neural circuits. There is an extensive literature on how specific types of memory engage different parts of the brain, and how neurons in these regions process and store information. Until recently, however, the mechanisms that determine how specific cells and synapses within a neural circuit (and not their neighbors) are recruited during learning have received little attention. Recent findings suggest that memory allocation is not random, but rather specific mechanisms regulate where information is stored within a neural circuit. Novel methods that allow tagging, imaging, activation and inactivation of neurons in behaving animals, promise to revolutionize studies of brain circuits, including memory allocation. Results from these studies are likely to have a considerable impact on both computer science as well as on the understanding of memory and its disorders.
登录
查看更多内容
影响因子：
34.7
作者：
Lee, Yong-Seok;Silva, Alcino J.
通讯作者：
Silva, Alcino J.
影响因子：
3.7
作者：
Mongiat LA;Espósito MS;Lombardi G;Schinder AF
通讯作者：
Schinder AF
影响因子：
64.8
作者：
Lee, Seok-Jin R.;Escobedo-Lozoya, Yasmin;Szatmari, Erzsebet M.;Yasuda, Ryohei
通讯作者：
Yasuda, Ryohei
影响因子：
56.9
作者：
Rumpel, S;LeDoux, J;Malinow, R
通讯作者：
Malinow, R
影响因子：
64.8
作者：
Losonczy, Attila;Makara, Judit K.;Magee, Jeffrey C.
通讯作者：
Magee, Jeffrey C.