Mechanical and Physical Regulation of Fibroblast-Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology.
Mechanical and Physical Regulation of Fibroblast-Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology.
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成纤维细胞-肌成纤维细胞转变的机械和物理调节：从细胞机械反应到组织病理学。
DOI：
10.3389/fbioe.2020.609653
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发表时间：
2020
影响因子：
5.7
通讯作者：
Kurniawan NA
中科院分区：
文献类型：
--
作者：
D'Urso M;Kurniawan NA
成纤维细胞是存在于整个人体中的细胞，其主要负责在组织内产生和维持细胞外基质（ECM）。它们具有改变组织内ECM的机械特性并转变为肌成纤维细胞的能力，肌成纤维细胞是一种通过细胞密度和蛋白质沉积的急剧增加与纤维化组织的发展相关的细胞类型。这种从成纤维细胞到成肌纤维细胞的转变--一种众所周知的组织病理状态的细胞标志--以及可以诱导这种转变的环境刺激已经受到了很多关注，例如在哮喘和心脏纤维化的背景下。最近在理解细胞如何在微米和纳米尺度上感知其物理环境方面的努力带来了新的认识，即细胞粘附的基底不仅提供被动影响，而且还提供可以影响成纤维细胞活化的主动刺激。这些研究表明，在细胞-基质界面的机械相互作用，通过改变细胞的机械和形态学特性，在调节这种表型转变中起着关键作用。在这里，我们简要地总结了报告的化学和物理线索调节成纤维细胞表型。然后，我们认为，更好地理解细胞如何与基质机械相互作用（机械传感）以及如何使用定义明确的平台影响细胞行为（机械转导），这些平台将物理刺激与化学刺激解耦，可以提供一个强大的工具来控制生理组织再生和病理纤维化反应之间的平衡。
Fibroblasts are cells present throughout the human body that are primarily responsible for the production and maintenance of the extracellular matrix (ECM) within the tissues. They have the capability to modify the mechanical properties of the ECM within the tissue and transition into myofibroblasts, a cell type that is associated with the development of fibrotic tissue through an acute increase of cell density and protein deposition. This transition from fibroblast to myofibroblast—a well-known cellular hallmark of the pathological state of tissues—and the environmental stimuli that can induce this transition have received a lot of attention, for example in the contexts of asthma and cardiac fibrosis. Recent efforts in understanding how cells sense their physical environment at the micro- and nano-scales have ushered in a new appreciation that the substrates on which the cells adhere provide not only passive influence, but also active stimulus that can affect fibroblast activation. These studies suggest that mechanical interactions at the cell–substrate interface play a key role in regulating this phenotype transition by changing the mechanical and morphological properties of the cells. Here, we briefly summarize the reported chemical and physical cues regulating fibroblast phenotype. We then argue that a better understanding of how cells mechanically interact with the substrate (mechanosensing) and how this influences cell behaviors (mechanotransduction) using well-defined platforms that decouple the physical stimuli from the chemical ones can provide a powerful tool to control the balance between physiological tissue regeneration and pathological fibrotic response.
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影响因子：
9.2
作者：
Bachir, Alexia I.;Zareno, Jessica;Moissoglu, Konstadinos;Plow, Edward F.;Gratton, Enrico;Horwitz, Alan R.
通讯作者：
Horwitz, Alan R.
影响因子：
2.1
作者：
Albrecht, Thomas R.;Arora, Hitesh;Yang, En
通讯作者：
Yang, En
影响因子：
6.1
作者：
Batra, V;Musani, AI;Peters, SP
通讯作者：
Peters, SP
细胞介导的纤维募集驱动工程原纤维微环境中的细胞外基质机械感应。
影响因子：
41.2
作者：
Baker BM;Trappmann B;Wang WY;Sakar MS;Kim IL;Shenoy VB;Burdick JA;Chen CS
通讯作者：
Chen CS
影响因子：
11.8
作者：
Changede, Rishita;Xu, Xiaochun;Sheetz, Michael P.
通讯作者：
Sheetz, Michael P.