The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID.
The Impact of COVID Vaccination on Symptoms of Long COVID: An International Survey of People with Lived Experience of Long COVID.
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DOI：
10.3390/vaccines10050652
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发表时间：
2022-04-21
期刊：
影响因子：
7.8
通讯作者：
Rossman, Jeremy
中科院分区：
文献类型：
--
作者：
Strain, William David;Sherwood, Ondine;Banerjee, Amitava;Van der Togt, Vicky;Hishmeh, Lyth;Rossman, Jeremy
长期COVID是SARS-CoV-2感染后的多系统综合征，症状持续至少4周，经常持续数月。有人认为可能有自身免疫成分。一些长期经历COVID的人有一种可以理解的警告，即通过增强免疫反应，COVID疫苗可能会加剧他们的症状。我们旨在调查长期患有COVID的人，评估他们首次接种COVID疫苗对其症状的影响。研究方法：长期COVID患者被邀请通过社交媒体上的帖子和支持团体的直接邮件完成基于网络的问卷。调查了他们接种疫苗前后的基本人口统计学、长期COVID症状的范围和严重程度。结果如下：900人参与了问卷调查，其中45人患有既存肌痛性脑脊髓炎或慢性疲劳综合征（ME/CFS），但没有新冠病毒感染的证据，另有43人没有完全完成调查。其余812人的人口统计学和生物学与英国国家统计局记录的相似。接种疫苗后，57.9%的参与者报告症状改善，17.9%报告恶化，其余无变化。个体的反应差异很大。与腺病毒载体疫苗相比，接受mRNA疫苗的患者症状严重程度评分有较大改善。结论：我们的调查表明，平均而言，COVID-19疫苗接种可能会改善长期COVID患者。调查的观察性质限制了直接的因果推断，但需要随机对照试验进行验证。
Long COVID is a multi-system syndrome following SARS-CoV-2 infection with persistent symptoms of at least 4 weeks, and frequently for several months. It has been suggested that there may be an autoimmune component. There has been an understandable caution amongst some people experiencing long COVID that, by boosting their immune response, a COVID vaccine may exacerbate their symptoms. We aimed to survey people living with long COVID, evaluating the impact of their first COVID vaccination on their symptoms. Methods: Patients with long COVID were invited to complete a web-based questionnaire through postings on social media and direct mailing from support groups. Basic demographics, range and severity of long COVID symptoms, before and after their vaccine, were surveyed. Results: 900 people participated in the questionnaire, of whom 45 had pre-existing myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) but no evidence of COVID infection, and a further 43 did not complete the survey in full. The demographics and symptomology of the remaining 812 people were similar to those recorded by the UK Office of National Statistics. Following vaccination, 57.9% of participants reported improvements in symptoms, 17.9% reported deterioration and the remainder no change. There was considerable individual variation in responses. Larger improvements in symptom severity scores were seen in those receiving the mRNA vaccines compared to adenoviral vector vaccines. Conclusions: Our survey suggests COVID-19 vaccination may improve long COVID patients, on average. The observational nature of the survey limits drawing direct causal inference, but requires validation with a randomised controlled trial.
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DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
DOI：
10.1016/s2213-2600(22)00020-0
发表时间：
2022-03
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Venkatesan P
通讯作者：
Venkatesan P
COVID-19 的 50 多种长期影响：系统回顾和荟萃分析。
影响因子：
4.6
作者：
Lopez-Leon S;Wegman-Ostrosky T;Perelman C;Sepulveda R;Rebolledo PA;Cuapio A;Villapol S
通讯作者：
Villapol S
影响因子：
4.4
作者：
O'Sullivan, Oliver
通讯作者：
O'Sullivan, Oliver
影响因子：
15.8
作者：
Taquet M;Dercon Q;Luciano S;Geddes JR;Husain M;Harrison PJ
通讯作者：
Harrison PJ