Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy.
Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy.
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DOI：
10.1038/s41467-020-18843-5
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发表时间：
2020-10-08
影响因子：
16.6
通讯作者：
Wedge DC
中科院分区：
文献类型：
--
作者：
Woodcock DJ;Riabchenko E;Taavitsainen S;Kankainen M;Gundem G;Brewer DS;Ellonen P;Lepistö M;Golubeva YA;Warner AC;Tolonen T;Jasu J;Isaacs WB;Emmert-Buck MR;Nykter M;Visakorpi T;Bova GS;Wedge DC
从原发癌到转移性前列腺癌的演变过程在很大程度上是未知的，液体活检的意义也是未知的。我们对10例前列腺癌患者的肿瘤系统进行了详细的重建，并结合组织病理学和从血液和脑脊液中提取的肿瘤DNA进行了研究。在前列腺内发生了实质性的进化，导致分支成多个空间混合的血统。出现了一个启动和驱动全身转移的显性谱系，其中在部位之间进行多克隆播种是常见的。不同患者的转移途径不同，转移的可能遗传驱动因素将转移谱系与每个患者体内仍局限于前列腺的谱系区分开来。体液捕捉优势谱系的特征，而发生在转移阶段的亚克隆扩张并不均匀地表现出来。脑脊液分析显示在血液传播的DNA中没有检测到谱系，这表明可能的临床实用价值。从原发癌到转移性前列腺癌的演变过程在很大程度上是未知的，液体活检的意义也是未知的。在这里，作者使用深入的基因组测序和组织病理学信息来追踪10名男性前列腺内和转移过程中的肿瘤演变。
The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tumor DNA extracted from blood and cerebrospinal fluid. Substantial evolution occurs within the prostate, resulting in branching into multiple spatially intermixed lineages. One dominant lineage emerges that initiates and drives systemic metastasis, where polyclonal seeding between sites is common. Routes to metastasis differ between patients, and likely genetic drivers of metastasis distinguish the metastatic lineage from the lineage that remains confined to the prostate within each patient. Body fluids capture features of the dominant lineage, and subclonal expansions that occur in the metastatic phase are non-uniformly represented. Cerebrospinal fluid analysis reveals lineages not detected in blood-borne DNA, suggesting possible clinical utility. The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. Here, the authors use deep genomic sequencing and histopathological information to trace tumor evolution both within the prostate and during metastasis in ten men.
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DOI：
10.1016/j.bbcan.2017.01.003
发表时间：
2017-04
期刊：
Biochimica et biophysica acta. Reviews on cancer
影响因子：
--
作者：
Davis A;Gao R;Navin N
通讯作者：
Navin N
影响因子：
16.6
作者：
Behjati, Sam;Gundem, Gunes;Wedge, David C.;Roberts, Nicola D.;Tarpey, Patrick S.;Cooke, Susanna L.;Van Loo, Peter;Alexandrov, Ludmil B.;Ramakrishna, Manasa;Davies, Helen;Nik-Zainal, Serena;Hardy, Claire;Latimer, Calli;Raine, Keiran M.;Stebbings, Lucy;Menzies, Andy;Jones, David;Shepherd, Rebecca;Butler, Adam P.;Teague, Jon W.;Jorgensen, Mette;Khatri, Bhavisha;Pillay, Nischalan;Shlien, Adam;Futreal, P. Andrew;Badie, Christophe;McDermott, Ultan;Bova, G. Steven;Richardson, Andrea L.;Flanagan, Adrienne M.;Stratton, Michael R.;Campbell, Peter J.
通讯作者：
Campbell, Peter J.
DOI：
10.1126/science.1253462
发表时间：
2014-10-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
de Bruin EC;McGranahan N;Mitter R;Salm M;Wedge DC;Yates L;Jamal-Hanjani M;Shafi S;Murugaesu N;Rowan AJ;Grönroos E;Muhammad MA;Horswell S;Gerlinger M;Varela I;Jones D;Marshall J;Voet T;Van Loo P;Rassl DM;Rintoul RC;Janes SM;Lee SM;Forster M;Ahmad T;Lawrence D;Falzon M;Capitanio A;Harkins TT;Lee CC;Tom W;Teefe E;Chen SC;Begum S;Rabinowitz A;Phillimore B;Spencer-Dene B;Stamp G;Szallasi Z;Matthews N;Stewart A;Campbell P;Swanton C
通讯作者：
Swanton C
影响因子：
64.5
作者：
Espiritu, Shadrielle Melijah G.;Liu, Lydia Y.;Boutros, Paul C.
通讯作者：
Boutros, Paul C.
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Ward, Elizabeth
通讯作者：
Ward, Elizabeth