Invited Article: Coherent Raman and mid-IR microscopy using shaped pulses in a single-beam setup
Invited Article: Coherent Raman and mid-IR microscopy using shaped pulses in a single-beam setup
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特邀文章：在单光束设置中使用整形脉冲的相干拉曼和中红外显微镜
作者：
N. Müller;L. Brückner;M. Motzkus
利用成形超宽带激光脉冲进行分子相干控制的可能性提供了在一个设置中的许多非线性光谱方法的独特实现。非线性过程，如相干拉曼显微镜，二次谐波产生，或双光子荧光，这已经应用在许多不同的应用在材料和生命科学，可以选择性地解决和优化，只是通过改变由可编程脉冲整形器压印的相位。在这里，这个概念的多模非线性显微镜的实验实现进行了讨论和成功实施的自适应光谱聚焦计划，不仅为非线性拉曼，但也为差频产生基于中红外（中红外）光谱使用一个单一的宽带脉冲从钛：蓝宝石激光器示出。灵活的脉冲整形能够调谐谐振频率和激励的频谱宽度。通过改变瞬时频率差和啁啾量，可以优化实验，以实现高达20 cm−1的高分辨率光谱。另一方面，将实验的分辨率与样品的线宽相匹配可以优化高信号水平下成像的对比度。拉曼或中红外激发光谱和显微镜之间的组合和灵活的切换被证明对炔，聚合物薄膜和皮肤组织。简单地将这种互补模式添加到现有的非线性显微镜中，是朝着多模式显微镜的通用激光激发源迈出的又一步，利用成形的超宽带激光脉冲进行分子相干控制的可能性提供了在一个设置中实现众多非线性光谱方法的独特方法。非线性过程，如相干拉曼显微镜，二次谐波产生，或双光子荧光，这已经应用在许多不同的应用在材料和生命科学，可以选择性地解决和优化，只是通过改变由可编程脉冲整形器压印的相位。在这里，这个概念的多模非线性显微镜的实验实现进行了讨论和成功实施的自适应光谱聚焦计划，不仅为非线性拉曼，但也为差频产生基于中红外（中红外）光谱使用一个单一的宽带脉冲从钛：蓝宝石激光器示出。灵活的脉冲整形能够调谐谐振频率和激励的频谱宽度。通过改变瞬时频率差和...
The possibility to exploit shaped ultrabroadband laser pulses for molecular coherent control offers a unique implementation of numerous nonlinear spectroscopic methods in one setup. Nonlinear processes, such as coherent Raman microscopy, second harmonic generation, or two-photon fluorescence, which have been applied in many different applications in both the material and life sciences, can be selectively addressed and optimized just by changing the phase imprinted by a programmable pulse shaper. Here, the experimental realization of this concept for multimodal nonlinear microscopy is discussed and the successful implementation of adaptive spectral focussing schemes not only for nonlinear Raman but also for difference frequency generation based mid-infrared (Mid-IR) spectroscopy using a single broadband pulse from a Ti:sapphire laser is shown. Flexible pulse shaping enables tuning of the resonance frequency and the spectral width of the excitation. By variation of the instantaneous frequency difference and the amount of chirp, the experiment can be optimized to achieve high resolution spectroscopy reaching up to 20 cm−1. Matching the resolution of the experiment with the linewidths of the sample on the other hand optimizes the contrast for imaging at high signal levels. The combination and flexible switching between Raman or mid-IR excitation for spectroscopy and microscopy is demonstrated on alkynes, polymer films, and skin tissue. The simple addition of this complementary modality to an existing nonlinear microscope is a further step toward an all-purpose laser excitation source for multimodal microscopy.The possibility to exploit shaped ultrabroadband laser pulses for molecular coherent control offers a unique implementation of numerous nonlinear spectroscopic methods in one setup. Nonlinear processes, such as coherent Raman microscopy, second harmonic generation, or two-photon fluorescence, which have been applied in many different applications in both the material and life sciences, can be selectively addressed and optimized just by changing the phase imprinted by a programmable pulse shaper. Here, the experimental realization of this concept for multimodal nonlinear microscopy is discussed and the successful implementation of adaptive spectral focussing schemes not only for nonlinear Raman but also for difference frequency generation based mid-infrared (Mid-IR) spectroscopy using a single broadband pulse from a Ti:sapphire laser is shown. Flexible pulse shaping enables tuning of the resonance frequency and the spectral width of the excitation. By variation of the instantaneous frequency difference and...
影响因子：
3.6
作者：
Raghunathan V;Han Y;Korth O;Ge NH;Potma EO
通讯作者：
Potma EO
影响因子：
3.4
作者：
Cheng, JX;Jia, YK;Xie, XS
通讯作者：
Xie, XS
影响因子：
35
作者：
Pupeza, I.;Sanchez, D.;Biegert, J.
通讯作者：
Biegert, J.