Low‑Level Environmental Heavy Metals are Associated with Obesity Among Postmenopausal Women in a Southern State.
Low‑Level Environmental Heavy Metals are Associated with Obesity Among Postmenopausal Women in a Southern State.
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低水平的环境重金属与南方州绝经后妇女的肥胖有关。
DOI：
10.1007/s12403-020-00381-6
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发表时间：
2021-06
影响因子：
6.7
通讯作者：
Joseph Su L
中科院分区：
文献类型：
--
作者：
Stahr S;Chiang TC;Bauer MA;Runnells GA;Rogers LJ;Vi Do H;Kadlubar SA;Joseph Su L
Both arsenic and cadmium are reported to be toxic to humans. The use of saliva as a biomarker of low-level exposures to these elements has not been adequately explored, and the putative relationship between exposure and obesity is unclear. This cross-sectional study aims to investigate the relationship between salivary arsenic and cadmium concentrations and their association with obesity. Arsenic and cadmium concentrations were analyzed in human saliva samples by Inductively Coupled Plasma-Mass Spectrometry on 270 randomly selected women who participated in the Arkansas Rural Community Health Study. Multivariable logistic regression was performed to evaluate the association between heavy metal concentrations and obesity. Stratified logistic regression was performed based on menopausal status. Generalized linear models were used to evaluate weight gain velocity. Significant positive associations were observed in postmenopausal women for both arsenic (OR = 4.43, 95% CI 1.91–10.28) and cadmium (OR = 2.72, 95% CI 1.23–5.99) concentrations, as well as significant trends among tertiles (p < 0.01 and p = 0.01, respectively). No relationship with obesity was evident among premenopausal women for either metal. A dose–response relationship was observed between increasing weight gain velocity and increasing metal concentrations. At concentrations well below governmental and industrial standards for acute toxicity, significant associations between obesity and concentration of these heavy metals are evident. The rate at which individuals gain weight is affected by metal concentrations and may play a role in the rapid increase in weight in postmenopausal women. These results might explain, in part, the missing variability in the increasing obesity pandemic in certain population exposed to these environmental toxicants.
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影响因子：
10.4
作者：
Bulka CM;Mabila SL;Lash JP;Turyk ME;Argos M
通讯作者：
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影响因子：
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作者：
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作者：
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作者：
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DOI：
10.1097/01.jom.0000205457.44750.9f
发表时间：
2006-06-01
影响因子：
3.2
作者：
Hopenhayn, Claudia;Bush, Heather M.;Hertz-Picciotto, Irva
通讯作者：
Hertz-Picciotto, Irva