The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19.
The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19.
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DOI：
10.1155/2021/3178796
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发表时间：
2021
影响因子：
--
通讯作者：
Luo Y
中科院分区：
文献类型：
--
作者：
Li X;Yan M;Chen J;Luo Y
由严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）的爆发，严重影响了公共卫生和社会稳定。传播的主要途径是飞沫传播，其中口腔是进入身体最重要的入口。由于SARS-CoV-2的直接有害影响和免疫反应紊乱，一些COVID-19患者可能发展为急性呼吸窘迫综合征甚至多器官衰竭。SARS-CoV-2的遗传变异已经出现并在世界各地传播。目前，没有国际上批准的针对COVID-19的精确治疗方法。间充质干细胞（Mesenchymal stem cells, MSCs）可以向受损组织运输和迁移，调节先天和获得性免疫系统，并参与愈合过程。在这里，我们将讨论和研究COVID-19免疫紊乱的机制以及MSCs，特别是人牙龈间充质干细胞的治疗活性。
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seriously affected public health and social stability. The main route of the transmission is droplet transmission, where the oral cavity is the most important entry point to the body. Due to both the direct harmful effects of SARS-CoV-2 and disordered immune responses, some COVID-19 patients may progress to acute respiratory distress syndrome or even multiple organ failure. Genetic variants of SARS-CoV-2 have been emerging and circulating around the world. Currently, there is no internationally approved precise treatment for COVID-19. Mesenchymal stem cells (MSCs) can traffic and migrate towards the affected tissue, regulate both the innate and acquired immune systems, and participate in the process of healing. Here, we will discuss and investigate the mechanisms of immune disorder in COVID-19 and the therapeutic activity of MSCs, in particular human gingiva mesenchymal stem cells.
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