Decidual macrophages are significantly increased in spontaneous miscarriages and over-express FasL: a potential role for macrophages in trophoblast apoptosis.
Decidual macrophages are significantly increased in spontaneous miscarriages and over-express FasL: a potential role for macrophages in trophoblast apoptosis.
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DOI：
10.3390/ijms13079069
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发表时间：
2012
影响因子：
5.6
通讯作者：
Jeschke U
中科院分区：
文献类型：
--
作者：
Guenther S;Vrekoussis T;Heublein S;Bayer B;Anz D;Knabl J;Navrozoglou I;Dian D;Friese K;Makrigiannakis A;Jeschke U
巨噬细胞（DM）是胎儿-母体界面中第二丰富的细胞群。到目前为止，它们的作用已被确定为局部免疫调节剂，有利于母亲对胎儿的耐受。在此，我们调查了11例自然流产和9例选择性终止妊娠的组织样本。使用免疫组织化学和双免疫荧光，我们已经证明自发性流产DM显著增加。此外，我们注意到巨噬细胞FasL表达显著上调。我们的研究结果进一步支持糖尿病在妊娠和流产期间的双重作用。我们假设正常妊娠的基线糖尿病人群符合支持妊娠的M2表型。相反，在自然流产期间，增加的fasl表达群体可能是参与Fas/ fasl相关凋亡的M1表型的一部分。我们的结果突出了巨噬细胞生物学在妊娠生理学和病理生理学中的一个新方面。需要更大样本的进一步研究来验证目前的结果并评估其临床影响。
Decidual macrophages (DM) are the second most abundant population in the fetal-maternal interface. Their role has been so far identified as being local immuno-modulators favoring the maternal tolerance to the fetus. Herein we investigated tissue samples from 11 cases of spontaneous miscarriages and from 9 cases of elective terminations of pregnancy. Using immunohistochemistry and dual immunofluorescence we have demonstrated that in spontaneous miscarriages the DM are significantly increased. Additionally, we noted a significant up-regulation of macrophage FasL expression. Our results further support a dual role for DM during pregnancy and miscarriages. We hypothesize that the baseline DM population in normal pregnancy is in line with an M2 phenotype supporting the ongoing gestation. In contrast, during spontaneous miscarriages, the increased FasL-expressing population could be a part of an M1 phenotype participating in Fas/FasL-related apoptosis. Our results highlight a new aspect of macrophage biology in pregnancy physiology and pathophysiology. Further studies with larger samples are needed to verify the current results and evaluate their clinical impact.
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影响因子：
15.9
作者：
Dockrell, DH;Badley, AD;Paya, CV
通讯作者：
Paya, CV
影响因子：
4.6
作者：
Heikkinen, J;Möttönen, M;Lassila, O
通讯作者：
Lassila, O
影响因子：
3.7
作者：
Dace DS;Khan AA;Stark JL;Kelly J;Cross AH;Apte RS
通讯作者：
Apte RS
影响因子：
3.7
作者：
Gustafsson C;Mjösberg J;Matussek A;Geffers R;Matthiesen L;Berg G;Sharma S;Buer J;Ernerudh J
通讯作者：
Ernerudh J
影响因子：
30.5
作者：
Makrigiannakis, A;Zoumakis, E;Chrousos, GP
通讯作者：
Chrousos, GP