Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans.

Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans.
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DOI:
10.1016/j.jneumeth.2020.109024
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发表时间:
2021-02-01
影响因子:
3
通讯作者:
Xu, Junzhong
Xu, Junzhong
中科院分区:
医学4区
文献类型:
--
作者:
Xu, Junzhong

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扩散核磁共振成像(dMRI)的检测灵敏度与扩散次数有关。较短的扩散时间可以提高对较小长度尺度的灵敏度。然而,传统的dMRI使用脉冲梯度自旋回波(PGSE)序列,仅探测相对较长的扩散时间。为了克服这个问题,振荡梯度自旋回波(OGSE)序列已经被开发出来,可以在临床前和临床MRI系统的硬件限制下探测更短的扩散时间。OGSE序列以前已用于临床前动物MRI系统。最近,一些研究已经将OGSE序列转化为临床MRI系统上的人类,并获得了使用传统PGSE序列无法看到的新信息。本文综述了OGSE人类神经成像的最新进展,包括OGSE序列转化为人类成像的技术改进以及在不同神经系统疾病和中风中的各种应用。讨论了OGSE序列未来可能的发展方向。
The detection sensitivity of diffusion MRI (dMRI) is dependent on diffusion times. A shorter diffusion time can increase the sensitivity to smaller length scales. However, the conventional dMRI uses the pulse gradient spin echo (PGSE) sequence that probes relatively long diffusion times only. To overcome this, the oscillating gradient spin echo (OGSE) sequence has been developed to probe much shorter diffusion times with hardware limitations on preclinical and clinical MRI systems. The OGSE sequence has been previously used on preclinical animal MRI systems. Recently, several studies have translated the OGSE sequence to humans on clinical MRI systems and achieved new information that is invisible using conventional PGSE sequence. This paper overviews the recent progress of the OGSE neuroimaging in humans, including the technical improvements in the translation of the OGSE sequence to human imaging and various applications in different neurological disorders and stroke. Some possible future directions of the OGSE sequence are also discussed.
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