Seabuckthorn Paste Protects Lipopolysaccharide-Induced Acute Lung Injury in Mice through Attenuation of Oxidative Stress.
Seabuckthorn Paste Protects Lipopolysaccharide-Induced Acute Lung Injury in Mice through Attenuation of Oxidative Stress.
复制标题
沙棘膏通过减轻氧化应激来保护脂多糖引起的小鼠急性肺损伤
DOI：
10.1155/2017/4130967
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发表时间：
2017
影响因子：
--
通讯作者：
Wan L
中科院分区：
文献类型：
--
作者：
Du L;Hu X;Chen C;Kuang T;Yin H;Wan L
氧化应激是内毒素诱导的急性肺损伤的主要机制之一。本研究探讨了SP对脂多糖（LPS）诱导的小鼠急性肺损伤的保护作用及其可能的机制。结果发现，SP对LPS刺激引起的体重减轻、肺组织微结构病变、经血管渗漏增加、丙二醛升高、超氧化物歧化酶和谷胱甘肽过氧化物酶水平降低均有持续的缓解作用，且呈剂量依赖性。此外，观察到SP治疗引起的核因子红系2相关因子2 （Nrf2）在肺核内的蓄积。我们的研究表明，SP通过维持氧化还原稳态对lps诱导的急性肺损伤具有显著的保护作用，其机制涉及Nrf2核易位和激活。
Oxidative stress is one of the major mechanisms implicated in endotoxin-induced acute lung injury. Seabuckthorn paste (SP), a traditional Tibetan medicine with high content of polyphenols and remarkable antioxidant activity, is commonly used in treating pulmonary diseases. In the present study, the protective effects and possible underlying mechanisms of SP on lipopolysaccharide- (LPS-) induced acute lung injury in mice were investigated. It was found that body weight loss, lung tissue microstructure lesions, transvascular leakage increase, malondialdehyde augmentation, and the reduction of superoxide dismutase and glutathione peroxidase levels caused by LPS challenge were all consistently relieved by SP treatment in a dose-dependent manner. Moreover, accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in lung nuclei caused by SP treatment was observed. Our study demonstrated that SP can provide significant protection against LPS-induced acute lung injury through maintaining redox homeostasis, and its mechanism involves Nrf2 nuclear translocation and activation.
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影响因子：
6
作者：
Al-Sawaf, Othman;Clarner, Tim;Wruck, Christoph Jan
通讯作者：
Wruck, Christoph Jan
影响因子：
4.4
作者：
CERAMI, A;IKEDA, Y;BEUTLER, B
通讯作者：
BEUTLER, B
影响因子：
4.8
作者：
Sato, K;Kadiiska, MB;Mason, RP
通讯作者：
Mason, RP
NRF2：氧化应激中的INRF2（KEAP1）信号传导。
影响因子：
7.4
作者：
Kaspar, James W.;Niture, Suryakant K.;Jaiswal, Anil K.
通讯作者：
Jaiswal, Anil K.
影响因子：
8.8
作者：
Debnath, Trishna;Park, Pyo-Jam;Lim, Beong Ou
通讯作者：
Lim, Beong Ou