Development and validation of the 40-item Glaucoma Visual Functioning Questionnaire.
Development and validation of the 40-item Glaucoma Visual Functioning Questionnaire.
复制标题
40 项青光眼视觉功能问卷的开发和验证
DOI：
10.1136/bjophthalmol-2021-320985
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发表时间：
2023-08
影响因子：
4.1
通讯作者：
Zhuo, Yehong
中科院分区：
文献类型：
--
作者：
Huang, Haishun;Lin, Junxiong;Luo, Man;Li, Zhidong;Zhu, Yingting;Han, Jiaxu;Jin, Ling;Li, Yiqing;Zhuo, Yehong
目的：评价青光眼视觉功能问卷（GVFQ-40）的心理测量学特性，以了解青光眼患者视觉功能的5个方面。在这项横断面观察性研究中，从中山眼科中心青光眼门诊招募了84名青光眼疑似患者（对照组）和270名青光眼患者。所有受试者在常规临床访视期间完成两份问卷：GVFQ-40和经验证的国家眼科研究所视觉功能问卷-25（NEI VFQ-25）。对GVFQ-40的判别效度、效标相关效度和结构效度进行了评价。一部分受试者完成GVFQ-40两次，间隔7-21天，以确定重测信度。青光眼患者的特定领域和总GVFQ-40评分显著高于对照组（视力较差）（所有p<0.001）。除轻度视野丧失组和对照组之间的“移动性”域比较外，所有成对亚组比较均具有统计学显著性（p=0.189）。在NEI VFQ-25的12个维度中，仅在2个维度上观察到这两组之间的显著差异。GVFQ-40结果显示与更好的眼睛平均偏差和视野指数（青光眼严重程度测量）有很强的相关性。探索性因素分析倾向于确认一个三域结构。重测组内相关系数高于0.927特定领域和总GVFQ-40分数。GVFQ-40具有良好的信度和效度。该指标可用于评价青光眼损害对视觉功能的影响，在干预效果评价中具有一定的应用潜力。 NCT 04722861。
To evaluate the psychometric properties of a newly designed questionnaire, the 40-item Glaucoma Visual Functioning Questionnaire (GVFQ-40), in a Chinese sample to capture the visual ability of patients with glaucomatous vision impairment in five domains. Eighty-four glaucoma suspects (controls) and 270 glaucoma patients were recruited from the Glaucoma Clinic at Zhongshan Ophthalmic Centre in this cross-sectional, observational study. All subjects completed two questionnaires during routine clinical visits: the GVFQ-40 and the validated National Eye Institute Visual Functioning Questionnaire-25 (NEI VFQ-25). The discriminant, criterion-related and construct validity of the GVFQ-40 were assessed. A subset of subjects completed the GVFQ-40 twice, with an interval of 7–21 days, to determine test–retest reliability. Domain-specific and total GVFQ-40 scores were significantly higher (worse visual ability) in glaucoma patients than in controls (all p<0.001). All pairwise subgroup comparisons were statistically significant except for the ‘mobility’ domain comparison between the mild visual field loss and control groups (p=0.189). Significant differences between these two groups were observed in only 2 of the 12 dimensions on the NEI VFQ-25. The GVFQ-40 results demonstrated strong correlations with better-eye mean deviation and Visual Field Index (glaucoma severity measures). Exploratory factor analysis tended to confirm a three-domain structure. Test–retest intraclass correlation coefficients were higher than 0.927 for domain-specific and total GVFQ-40 scores. The GVFQ-40 possesses good validity and reliability. It can be used to evaluate the impact of glaucomatous damage on visual ability and has potential in the evaluation of intervention efficacy. NCT04722861.
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